ArticleEukaryotic cell2007
Characterization of a novel gene for strain typing reveals substructuring of Aspergillus fumigatus across North America.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Development and application of a novel beta-tubulin genotyping tool reveals host-specific transmission cluster in Balantioides coli.PLoS neglected tropical diseases · 2025Article
- Epidemiology of Clinically SignificantInfection and drug resistance · 2023Article
- Phylogenetic Distribution ofMicrobiology spectrum · 2021Article
- Epidemiological Studies of Pan-Azole ResistantMicroorganisms · 2021Article
- Review
- Molecular Epidemiology ofJournal of fungi (Basel, Switzerland) · 2021Review
- Identification of CSP Types and Genotypic Variability of Clinical and Environmental Isolates ofMicroorganisms · 2020Article
- The Multi-Fungicide Resistance Status ofFrontiers in microbiology · 2020Article
- Article
- Comparison of Two Highly Discriminatory Typing Methods to AnalyzeFrontiers in microbiology · 2018Article
- Investigating Clinical Issues by Genotyping of Medically Important Fungi: Why and How?Clinical microbiology reviews · 2017Review
- Article
- Genetic Diversity andAntimicrobial agents and chemotherapy · 2017Article
- Evaluation of Polymorphic Locus Sequence Typing for Candida glabrata Epidemiology.Journal of clinical microbiology · 2016Article
- Quantitative Analysis of Single-Nucleotide Polymorphism for Rapid Detection of TR34/L98H- and TR46/Y121F/T289A-Positive Aspergillus fumigatus Isolates Obtained from Patients in Iran from 2010 to 2014.Antimicrobial agents and chemotherapy · 2016Article
- Article
- The first case of feline sinonasal aspergillosis due to Aspergillus fischeri in Japan.The Journal of veterinary medical science · 2015Article
- Environmental isolates of azole-resistant Aspergillus fumigatus in Germany.Antimicrobial agents and chemotherapy · 2015Article
- Phylogenetic analyses on the diversity of Aspergillus fumigatus sensu lato based on five orthologous loci.Mycopathologia · 2014Article
- Genetic structure of Aspergillus flavus populations in human and avian isolates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013Article
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Authors and funding
5 authors.
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Abstract
Fifty-five epidemiologically linked Aspergillus fumigatus isolates obtained from six nosocomial outbreaks of invasive aspergillosis were subtyped by sequencing the polymorphic region of the gene encoding a putative cell surface protein, Afu3g08990 (denoted as CSP). Comparative sequence analysis showed that genetic diversity was generated in the coding region of this gene by both tandem repeats and point mutations. Each unique sequence in an outbreak cluster was assigned an arbitrary number or CSP sequence type. The CSP typing method was able to identify "clonal" and genotypically distinct A. fumigatus isolates, and the results of this method were concordant with those of another discriminatory genotyping technique, the Afut1 restriction fragment length polymorphism typing method. The novel single-locus sequence typing (CSP typing) strategy appears to be a simple, rapid, discriminatory tool that can be readily shared across laboratories. In addition, we found that A. fumigatus isolates substructured into multiple clades; interestingly, one clade consisted of isolates predominantly representing invasive clinical isolates recovered from cardiac transplant patients from two different outbreak situations. We also found that the A. fumigatus isolate Af293, whose genome has been sequenced, possesses a CSP gene structure that is substantially different from those of the other A. fumigatus strains studied here, highlighting the need for further taxonomic study.
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