ArticleEukaryotic cell2007
Unusually low levels of genetic variation among Giardia lamblia isolates.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 80 citations in OpenAlex.
- Comparative genomics of Giardia duodenalis sub-assemblage AI beaver (Be-2) and human (WB-C6) strains show remarkable homozygosity, sequence similarity, and conservation of VSP genes.Scientific reports · 2024Article
- Genotypic and Epidemiologic Profiles of Giardia duodenalis in Four Brazilian Biogeographic RegionsMicroorganisms · 2022Article
- Zoonotic giardiasis: an update.Parasitology research · 2021Review
- Multilocus Genotyping ofPathogens (Basel, Switzerland) · 2021Article
- Molecular diversity of Giardia duodenalis in children under 5 years from the Manhiça district, Southern Mozambique enrolled in a matched case-control study on the aetiology of diarrhoea.PLoS neglected tropical diseases · 2021Article
- The controversies surroundingCurrent research in parasitology & vector-borne diseases · 2021Review
- Article
- Genetic Diversity of the Flavohemoprotein Gene ofInfection and drug resistance · 2020Article
- Genetic variation in metronidazole metabolism and oxidative stress pathways in clinicalInfection and drug resistance · 2019Article
- Population expansion and gene flow in Giardia duodenalis as revealed by triosephosphate isomerase gene.Parasites & vectors · 2015Article
- Molecular Genotyping of Giardia duodenalis Isolates from Symptomatic Individuals Attending Two Major Public Hospitals in Madrid, Spain.PloS one · 2015Article
- Giardia duodenalis and Cryptosporidium occurrence in Australian sea lions (Neophoca cinerea) exposed to varied levels of human interaction.International journal for parasitology. Parasites and wildlife · 2014Article
- Suitability of internal transcribed spacers (ITS) as markers for the population genetic structure of Blastocystis spp.Parasites & vectors · 2014Article
- Article
- Molecular typing of Giardia duodenalis isolates from German travellers.Parasitology research · 2013Article
- Homologous recombination occurs in Entamoeba and is enhanced during growth stress and stage conversion.PloS one · 2013Article
- Nuclear inheritance and genetic exchange without meiosis in the binucleate parasite Giardia intestinalis.Journal of cell science · 2012Article
- Clonal diversity of the glutamate dehydrogenase gene in Giardia duodenalis from Thai isolates: evidence of genetic exchange or mixed infections?BMC microbiology · 2011Article
- Barcoding of Giardia duodenalis isolates and derived lines from an established cryobank by a mutation scanning-based approach.Electrophoresis · 2011Article
- Zoonotic potential and molecular epidemiology of Giardia species and giardiasis.Clinical microbiology reviews · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Giardia lamblia, an intestinal pathogen of mammals, including humans, is a significant cause of diarrheal disease around the world. Additionally, the parasite is found on a lineage which separated early from the main branch in eukaryotic evolution. The extent of genetic diversity among G. lamblia isolates is insufficiently understood, but this knowledge is a prerequisite to better understand the role of parasite variation in disease etiology and to examine the evolution of mechanisms of genetic exchange among eukaryotes. Intraisolate genetic variation in G. lamblia has never been estimated, and previous studies on interisolate genetic variation have included a limited sample of loci. Here we report a population genetics study of intra- and interisolate genetic diversity based on six coding and four noncoding regions from nine G. lamblia isolates. Our results indicate exceedingly low levels of genetic variation in two out of three G. lamblia groups that infect humans; this variation is sufficient to allow identification of isolate-specific markers. Low genetic diversity at both coding and noncoding regions, with an overall bias towards synonymous substitutions, was discovered. Surprisingly, we found a dichotomous haplotype structure in the third, more variable G. lamblia group, represented by a haplotype shared with one of the homogenous groups and an additional group-specific haplotype. We propose that the distinct patterns of genetic-variation distribution among lineages are a consequence of the presence of genetic exchange. More broadly, our findings have implications for the regulation of gene expression, as well as the mode of reproduction in the parasite.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.