ArticleJournal of clinical pathology2007
Indefinite for non-invasive neoplasia lesions in gastric intestinal metaplasia: the immunophenotype.
Article in Journal of clinical pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- Role of magnifying endoscopy with narrow-band imaging in the diagnosis of noninvasive gastric neoplasia.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Association of HER2 gene amplification and tumor progression in early gastric cancer.Virchows Archiv : an international journal of pathology · 2018Article
- HER2 heterogeneity in gastric/gastroesophageal cancers: From benchside to practice.World journal of gastroenterology · 2016Review
- HER2 Status in Premalignant, Early, and Advanced Neoplastic Lesions of the Stomach.Disease markers · 2015Review
- High-throughput mutation profiling identifies novel molecular dysregulation in high-grade intraepithelial neoplasia and early gastric cancers.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2014Article
- hTERT and TP53 deregulation in intestinal-type gastric carcinogenesis in non-human primates.Clinical and experimental medicine · 2013Article
- hTERT, MYC and TP53 deregulation in gastric preneoplastic lesions.BMC gastroenterology · 2012Article
- miRNAs in precancerous lesions of the gastrointestinal tract.World journal of gastroenterology · 2011Review
- Secondary prevention of gastric cancer.Gut · 2007Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the Padova International Classification, gastric precancerous lesions are labelled as "indefinite for non-invasive neoplasia" (Indef-NiN) cytohistological alterations mimicking non-invasive neoplasia (NiN), but lacking all the attributes required for a definite NiN categorisation.
aimTo apply a panel of immunohistochemical (IHC) markers of cell proliferation (Mib1), intestinal differentiation (Cdx2), apoptosis (pro-caspase 3) and cell immortalisation (hTERT) to compare the IHC profiles of a series of precancerous lesions arising in gastric intestinalised (ie, IM-positive) glands. MATERIALS AND
methodsBy applying the histological criteria consistently provided by both the Padova Classification and the World Health Organization International Agency, 112 consecutive cases were considered: intestinal metaplasia (IM; n = 54), Indef-NiN in IM-positive gastric glands (n = 28) and low-grade (LG) NiN (n = 30). In each histological category, the expression of the marker was separately scored in superficial, proliferative and coil compartments.
resultsIn all glandular compartments, Mib1, Cdx2, hTERT and pro-caspase 3 were consistently more expressed in LG-NiN than in either IM or Indef-NiN lesions (analysis of variance: p<0.001). Significant ORs (calculated by ordinal logistic regression analysis for each glandular compartment) associated IM, Indef-NiN and LG-NiN with the expression of the considered markers.
conclusionsA consistent overexpression (unrestricted to the proliferative zone) of IHC markers of cell proliferation, intestinal differentiation, decreased apoptosis and cell immortalisation differentiates LG-NiN from both (simple) IM and Indef-NiN (arising in IM). An increased proliferative activity in the proliferative zone discriminates Indef-NiN lesions (ie, hyperproliferative IM) from IM. Such divergent IHC profiles may provide a rationale for scheduling follow-up protocols more properly tailored on the patient's risk for cancer.
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