ArticleApplied and environmental microbiology2007
Sinorhizobium meliloti fur-like (Mur) protein binds a fur box-like sequence present in the mntA promoter in a manganese-responsive manner.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Zur: Zinc-Sensing Transcriptional Regulator in a Diverse Set of Bacterial Species.Pathogens (Basel, Switzerland) · 2021Review
- Functional insights into the interplay between DNA interaction and metal coordination in ferric uptake regulators.Scientific reports · 2018Article
- Identification, Functional Characterization, and Regulon Prediction of the Zinc Uptake Regulator (Frontiers in microbiology · 2018Article
- A transcription network of interlocking positive feedback loops maintains intracellular iron balance in archaea.Nucleic acids research · 2017Article
- Manganese transport is essential for NEnvironmental microbiology · 2017Article
- Metal-specific control of gene expression mediated by Bradyrhizobium japonicum Mur and Escherichia coli Fur is determined by the cellular context.Molecular microbiology · 2016Article
- Discrete Responses to Limitation for Iron and Manganese in Agrobacterium tumefaciens: Influence on Attachment and Biofilm Formation.Journal of bacteriology · 2015Article
- Magnesium-dependent processes are targets of bacterial manganese toxicity.Molecular microbiology · 2014Article
- Differential control of Bradyrhizobium japonicum iron stimulon genes through variable affinity of the iron response regulator (Irr) for target gene promoters and selective loss of activator function.Molecular microbiology · 2014Article
- Manganese uptake in marine bacteria; the novel MntX transporter is widespread in Roseobacters, Vibrios, Alteromonadales and the SAR11 and SAR116 clades.The ISME journal · 2013Article
- Manganese is required for oxidative metabolism in unstressed Bradyrhizobium japonicum cells.Molecular microbiology · 2012Article
- Mur regulates the gene encoding the manganese transporter MntH in Brucella abortus 2308.Journal of bacteriology · 2012Article
- Bacterial outer membrane channel for divalent metal ion acquisition.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Antiparallel and interlinked control of cellular iron levels by the Irr and RirA regulators of Agrobacterium tumefaciens.Journal of bacteriology · 2011Article
- Transcriptional control of the Bradyrhizobium japonicum irr gene requires repression by fur and Antirepression by Irr.The Journal of biological chemistry · 2010Article
- Roles of Agrobacterium tumefaciens RirA in iron regulation, oxidative stress response, and virulence.Journal of bacteriology · 2009Article
- The mntH gene encodes the major Mn(2+) transporter in Bradyrhizobium japonicum and is regulated by manganese via the Fur protein.Molecular microbiology · 2009Article
- Heme-dependent metalloregulation by the iron response regulator (Irr) protein in Rhizobium and other Alpha-proteobacteria.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2009Article
- Functional definition and global regulation of Zur, a zinc uptake regulator in a Streptococcus suis serotype 2 strain causing streptococcal toxic shock syndrome.Journal of bacteriology · 2008Article
- The Bradyrhizobium japonicum Irr protein is a transcriptional repressor with high-affinity DNA-binding activity.Journal of bacteriology · 2008Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Sinorhizobium meliloti, the Mur(Sm) protein, a homologue of the ferric uptake regulator (Fur), mediates manganese-dependent regulation of the MntABCD manganese uptake system. In this study, we analyzed Mur(Sm) binding to the promoter region of the S. meliloti mntA gene. We demonstrated that Mur(Sm) protein binds with high affinity to the promoter region of mntA gene in a manganese-responsive manner. Moreover, the results presented here indicate that two monomers, or one dimer, of Mur(Sm) binds the DNA. The binding region was identified by DNase I footprinting analysis and covers a region of about 30 bp long that contains a palindromic sequence. The Mur(Sm) binding site, present in the mntA promoter region, is similar to a Fur box; however, manganese-activated Mur(Sm) binds a canonical Fur box with very low affinity. Furthermore, the data obtained indicate that Mur(Sm) responds to physiological concentrations of manganese.
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