ArticleParasitology research2007
Chronic steroid administration does not suppress Plasmodium development and maturation.
Article in Parasitology research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Dexamethasone increased the survival rate in Plasmodium berghei-infected mice.Scientific reports · 2021Article
- Complication of corticosteroid treatment by acute Plasmodium malariae infection confirmed by small-subunit rRNA sequencing.Journal of clinical microbiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to investigate the influence of constant steroid uptake on the Plasmodium yoelii infection rate and parasite maturation. On the animal model, we examined the effect(s) of dexamethasone (Dx), the general drug used for self-treatment by Thai villagers. Ten female ICR mice were subjected to oral administration of 0.5 mg/kg Dx for 40 days, whereas other ten were given drinking water only before P. yoelii 17X (lethal) strain inoculation. Parasite-infected erythrocytes were verified by Giemsa staining under light microscope. The differences of infectivity and maturation were evaluated by Student's t test. Parasitemia was detected in both groups on day 1 and increased until day 6 with similar infection rates. Significant lower numbers of ring, trophozoite, and schizont stages in the control group at the same time compared to Dx-treated mice were noted. The parasite maturation in infected Dx-treated mice appeared faster in comparison to the control. We conclude that the chronic taking of Dx suppresses the host immunity, without any suppressive effects on the parasite development and maturation, and, on the contrary, increases the development and maturation of P. yoelii.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.