ArticleThe EMBO journal2007
Constitutive activation of a plasma membrane H(+)-ATPase prevents abscisic acid-mediated stomatal closure.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers.
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Who cites it
156 citing papers in PubMed, 344 citations in OpenAlex.
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- Multi-physics modeling for ion homeostasis in multi-compartment plant cells using an energy function.PLoS computational biology · 2025Article
- Identification of a novel stomatal opening chemical, PP242, that inhibits early abscisic acid signal transduction in guard cells.Plant & cell physiology · 2025Article
- A PIF-SAUR module safeguards hypocotyl elongation from ABA inhibition in the dark.Science advances · 2025Article
- PROTON ATPASE TRANSLOCATION CONTROL 1-mediated HPNAS nexus · 2025Article
- Water immunity overrides stomatal immunity in plant resistance to Pseudomonas syringae.Plant physiology · 2025Article
- Physiological and transcriptomic evaluation of salt tolerance in Egyptian tomato landraces at the seedling stage.BMC plant biology · 2025Article
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- Phosphorylation of Arabidopsis NRT1.1 regulates plant stomatal aperture and drought resistance in low nitrate condition.BMC plant biology · 2025Article
- Stomatal opening under high temperatures is controlled by the OST1-regulated TOT3-AHA1 module.Nature plants · 2025Article
- TOT3-AHA1 module: its role in fine-tuning stomatal responses.Frontiers in plant science · 2025Review
- Applications of CRISPR/Cas tools in improving stress tolerance inFrontiers in plant science · 2025Review
- Dual function of overexpressing plasma membrane HScience advances · 2024Article
96 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light activates proton (H(+))-ATPases in guard cells, to drive hyperpolarization of the plasma membrane to initiate stomatal opening, allowing diffusion of ambient CO(2) to photosynthetic tissues. Light to darkness transition, high CO(2) levels and the stress hormone abscisic acid (ABA) promote stomatal closing. The overall H(+)-ATPase activity is diminished by ABA treatments, but the significance of this phenomenon in relationship to stomatal closure is still debated. We report two dominant mutations in the OPEN STOMATA2 (OST2) locus of Arabidopsis that completely abolish stomatal response to ABA, but importantly, to a much lesser extent the responses to CO(2) and darkness. The OST2 gene encodes the major plasma membrane H(+)-ATPase AHA1, and both mutations cause constitutive activity of this pump, leading to necrotic lesions. H(+)-ATPases have been traditionally assumed to be general endpoints of all signaling pathways affecting membrane polarization and transport. Our results provide evidence that AHA1 is a distinct component of an ABA-directed signaling pathway, and that dynamic downregulation of this pump during drought is an essential step in membrane depolarization to initiate stomatal closure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.