ArticleProceedings of the National Academy of Sciences of the United States of America2007
Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 114 citations in OpenAlex.
- ANRIL Promoter DNA Methylation: A Perinatal Marker for Later Adiposity.EBioMedicine · 2017Trial
- RB1 controls differentiation through positive regulation of phosphoglycerate mutases.Cell death & disease · 2025Article
- Review
- Relevance of pRB Loss in Human Malignancies.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Review
- CDK4: a master regulator of the cell cycle and its role in cancer.Genes & cancer · 2022Review
- p107 mediated mitochondrial function controls muscle stem cell proliferative fates.Nature communications · 2021Article
- Lower miR-26a levels in breastmilk affect gene expression in adipose tissue of offspring.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice.Scientific reports · 2021Article
- Cyclin-dependent kinase 4/6 inhibitors require an arcuate-to-paraventricular hypothalamus melanocortin circuit to treat diet-induced obesity.American journal of physiology. Endocrinology and metabolism · 2021Article
- CDK2 limits the highly energetic secretory program of mature β cells by restricting PEP cycle-dependent KCell reports · 2021Article
- Emerging Roles for theBiomolecules · 2020Review
- Loss ofCancers · 2020Article
- Regulation of E2F1 activity via PKA-mediated phosphorylations.Turkish journal of biology = Turk biyoloji dergisi · 2020Article
- Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase.Frontiers in molecular biosciences · 2020Review
- Article
- Role of cell cycle regulators in adipose tissue and whole body energy homeostasis.Cellular and molecular life sciences : CMLS · 2018Review
- Dietary Proteins, Brown Fat, and Adiposity.Frontiers in physiology · 2018Review
- E2F1, a Novel Regulator of Metabolism.Frontiers in endocrinology · 2017Review
- E2F6 Impairs Glycolysis and Activates BDH1 Expression Prior to Dilated Cardiomyopathy.PloS one · 2017Article
- Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies.World journal of stem cells · 2016Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the tumor suppressor retinoblastoma protein (pRb) has been firmly established in the control of cell cycle, apoptosis, and differentiation. Recently, it was demonstrated that lack of pRb promotes a switch from white to brown adipocyte differentiation in vitro. We used the Cre-Lox system to specifically inactivate pRb in adult adipose tissue. Under a high-fat diet, pRb-deficient (pRb(ad-/-)) mice failed to gain weight because of increased energy expenditure. This protection against weight gain was caused by the activation of mitochondrial activity in white and brown fat as evidenced by histologic, electron microscopic, and gene expression studies. Moreover, pRb(-/-) mouse embryonic fibroblasts displayed higher proliferation and apoptosis rates than pRb(+/+) mouse embryonic fibroblasts, which could contribute to the altered white adipose tissue morphology. Taken together, our data support a direct role of pRb in adipocyte cell fate determination in vivo and suggest that pRb could serve as a potential therapeutic target to trigger mitochondrial activation in white adipose tissue and brown adipose tissue, favoring an increase in energy expenditure and subsequent weight loss.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.