ArticleGenome research2007
Differing patterns of selection in alternative and constitutive splice sites.
Article in Genome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Ancestral splice variation is a key substrate for rapid diversification in African cichlids.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Benchmarking foundation models for splice site and exon annotation.bioRxiv : the preprint server for biology · 2026Article
- Evolutionarily Developed Alternatively Spliced Exons Containing Translation Initiation Sites.Cells · 2024Article
- Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing.Genome biology · 2024Article
- mRNA splicing is modulated by intronic microRNAs.iScience · 2023Article
- Long non-coding RNAs: definitions, functions, challenges and recommendations.Nature reviews. Molecular cell biology · 2023Review
- Intronization Signatures in Coding Exons Reveal the Evolutionary Fluidity of Eukaryotic Gene Architecture.Microorganisms · 2022Article
- Synthetic polycistronic sequences in eukaryotes.Synthetic and systems biotechnology · 2021Review
- Gallop Racing Shifts Mature mRNA towards Introns: Does Exercise-Induced Stress Enhance Genome Plasticity?Genes · 2020Article
- Article
- Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans.Aging cell · 2016Article
- RNA-Seq Analysis of Differential Splice Junction Usage and Intron Retentions by DEXSeq.PloS one · 2015Article
- The exon junction complex is required for definition and excision of neighboring introns in Drosophila.Genes & development · 2014Article
- Weak negative and positive selection and the drift load at splice sites.Genome biology and evolution · 2014Article
- NFAT1 and NFAT3 cooperate with HDAC4 during regulation of alternative splicing of PMCA isoforms in PC12 cells.PloS one · 2014Article
- Function of alternative splicing.Gene · 2013Review
- DNA hypermethylation of alternatively spliced and repeat sequences in humans.Molecular genetics and genomics : MGG · 2012Article
- Bioinformatic analysis of the human DHRS4 gene cluster and a proposed mechanism for its transcriptional regulation.BMC molecular biology · 2010Article
- Alternative-splicing-based bicistronic vectors for ratio-controlled protein expression and application to recombinant antibody production.Nucleic acids research · 2009Article
- Complex selection on 5' splice sites in intron-rich organisms.Genome research · 2009Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to allowing identification of putative functional elements as regions having reduced substitution rates, comparison of genome sequences can also provide insights into these elements at the nucleotide level, by indicating the pattern of tolerated substitutions. We created data sets of orthologous alternative and constitutive splice sites in mouse, rat, and human and analyzed the substitutions occurring within them. Our results illuminate differences between alternative and constitutive sites and, in particular, strongly support the idea that alternative sites are under selection to be weak.
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