ReviewThe Journal of physiology2007
Elementary properties of spontaneous fusion of peptidergic vesicles: fusion pore gating.
Review in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Catecholamine exocytosis during low frequency stimulation in mouse adrenal chromaffin cells is primarily asynchronous and controlled by the novel mechanism of Ca2+ syntilla suppression.The Journal of physiology · 2014Article
- Porosome: a membrane microdomain acting as the universal secretory portal in exocytosis.Discoveries (Craiova, Romania) · 2014Review
- Cell secretion and membrane fusion: highly significant phenomena in the life of a cell.Discoveries (Craiova, Romania) · 2014Article
- Single-vesicle architecture of synaptobrevin2 in astrocytes.Nature communications · 2014Article
- Imaging of kiss-and-run exocytosis of surface receptors in neuronal cultures.Frontiers in cellular neuroscience · 2014Article
- Amperometric resolution of a prespike stammer and evoked phases of fast release from retinal bipolar cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Myosin 2 maintains an open exocytic fusion pore in secretory epithelial cells.Molecular biology of the cell · 2009Article
- Synaptic vesicle endocytosis: fast and slow modes of membrane retrieval.Trends in neurosciences · 2008Review
- Water soluble single-walled carbon nanotubes inhibit stimulated endocytosis in neurons.Nano letters · 2008Article
- Hypotonicity and peptide discharge from a single vesicle.American journal of physiology. Cell physiology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The release of hormones and neurotransmitters by regulated exocytosis requires the delivery of secretory vesicles to the plasma membrane, where they dock and become primed for fusion with the plasma membrane. Upon stimulation a fusion pore is formed through which cargo molecules diffuse out of the vesicle lumen into the extracellular space. After the cargo release the fusion pore either closes (kiss-and-run, transient exocytosis), fluctuates between an open and a closed state (for short times, fusion pore flickering, or for rather longer periods, 'pulsing pore') or expands irreversibly (full fusion exocytosis). In almost all secretory cells spontaneous secretion of vesicle cargo can be detected in the absence of stimulation. Spontaneous and stimulated exocytosis were thought to exhibit similar properties at elementary level, differing only in the probability of occurrence. However, recent studies indicate that spontaneous exocytosis differs from the stimulated one in many respects, therefore opening questions about the physiological role of spontaneous exocytosis. In this report we address the elementary properties of spontaneous and stimulated peptidergic vesicle discharge which appears to be modulated by fusion pore conductance (diameter) and fusion pore gating.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.