ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Severe coronary artery calcifications are associated with ischemia in patients undergoing medical therapy.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Combined evaluation of CAC score and myocardial perfusion imaging in patients at risk of cardiovascular disease: where are we and what do the data say.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Comparison of different calcium supplementation methods in patients with osteoporosis.Experimental and therapeutic medicine · 2020Article
- Relationship between Calcium Score and Myocardial Scintigraphy in the Diagnosis of Coronary Disease.Arquivos brasileiros de cardiologia · 2016Review
- Computed tomography detection of carotid calcium and subclinical carotid atherosclerosis.The international journal of cardiovascular imaging · 2012Article
- Coronary artery calcium scores: current thinking and clinical applications.The open cardiovascular medicine journal · 2008Article
- The importance of the link between coronary artery calcification and myocardial ischemia: a developing argument.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- Witnessing ischemia or proofing coronary atherosclerosis: two different windows on the same or on different pathways precipitating cardiovascular events?Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyReview
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of coronary artery calcification (CAC) detection in individuals undergoing medical therapy is controversial. These patients frequently exhibit an artificially low clinical suspicion for obstructive heart disease. Whether detection of CAC adds value to their assessment is unknown. METHODS AND
resultsWe conducted a cross-sectional analysis of 703 adequately treated individuals who had CAC scoring with electron beam computed tomography and myocardial perfusion imaging within 6 months. We assessed the association of risk factor analysis and CAC scoring with myocardial perfusion imaging abnormalities. Univariate associations between ischemia and male gender, low high-density lipoprotein, high body mass index, diabetes, and CAC score were noted. Despite reasonable control of blood pressure and low-density lipoprotein, the prevalence of inducible ischemia was 0.8%, 4.8%, 5.7%, 8.0%, and 15.1% across CAC scores of 0 to 10, 11 to 100, 101 to 400, 401 to 1000, and greater than 1000, respectively (P < .001 for trend). Logistic regression analysis demonstrated that, after adjustment for risk factors, the odds of ischemia was 3.0 (95% confidence interval, 1.5-5.7) in individuals with CAC scores greater than 400 compared with those with CAC scores of 400 or less.
conclusionsThe presence of a CAC score greater than 400 is associated with ischemia in a population receiving good medical therapy. The detection of significant CAC in these individuals warrants additional evaluation for ischemia.
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