ArticleVirology journal2007
Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection.
Article in Virology journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
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- A small molecule compound berberine as an orally active therapeutic candidate against COVID-19 and SARS: A computational and mechanistic study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
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- Identification of multipotent drugs for COVID-19 therapeutics with the evaluation of their SARS-CoV2 inhibitory activity.Computational and structural biotechnology journal · 2021Article
- Polyunsaturated fatty acid biosynthesis pathway and genetics. implications for interindividual variability in prothrombotic, inflammatory conditions such as COVID-19Prostaglandins, leukotrienes, and essential fatty acids · 2020Review
- Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication.bioRxiv : the preprint server for biology · 2020Article
- Vaccines and Therapies in Development for SARS-CoV-2 Infections.Journal of clinical medicine · 2020Review
- COVID-19 Usurps Host Regulatory Networks.Frontiers in pharmacology · 2020Review
- Celebrex Adjuvant Therapy on Coronavirus Disease 2019: An Experimental Study.Frontiers in pharmacology · 2020Article
- Host transcriptome-guided drug repurposing for COVID-19 treatment: a meta-analysis based approach.PeerJ · 2020Article
- CD200 receptor controls sex-specific TLR7 responses to viral infection.PLoS pathogens · 2012Article
- Qualitative and quantitative ultrastructural analysis of the membrane rearrangements induced by coronavirus.Cellular microbiology · 2010Article
- Dynamics of coronavirus replication-transcription complexes.Journal of virology · 2010Article
- Type I interferon receptor-independent and -dependent host transcriptional responses to mouse hepatitis coronavirus infection in vivo.BMC genomics · 2009Article
- Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells.European journal of pharmacology · 2008Article
- Improved microarray gene expression profiling of virus-infected cells after removal of viral RNA.BMC genomics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production. Thus, COX activity appears to be required for efficient MHV replication, providing a potential target for anti-coronaviral therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.