ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Nuclear factor I coordinates multiple phases of cerebellar granule cell development via regulation of cell adhesion molecules.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 83 citations in OpenAlex.
- Alignment-free integration of single-nucleus ATAC-seq across species with sPYce.Nature ecology & evolution · 2026Article
- Structural basis for genome-wide site-specific DNA recognition by Nuclear Factor IA.Nature communications · 2025Article
- Spinal motor neuron development and metabolism are transcriptionally regulated by nuclear factor IA.Science advances · 2025Article
- Nuclear Factor I Family Members are Key Transcription Factors Regulating Gene Expression.Molecular & cellular proteomics : MCP · 2025Article
- Roles of the NFI/CTF gene family in transcription and development: update 2025.Academia biology · 2025Article
- Article
- Identification and characterization of transcribed enhancers during cerebellar development through enhancer RNA analysis.BMC genomics · 2023Article
- Building better brains: the pleiotropic function of neurotrophic factors in postnatal cerebellar development.Frontiers in molecular neuroscience · 2023Review
- Article
- Hepatocyte-Specific Knock-Out of Nfib Aggravates Hepatocellular Tumorigenesis via Enhancing Urea Cycle.Frontiers in molecular biosciences · 2022Article
- Capicua regulates the development of adult-born neurons in the hippocampus.Scientific reports · 2021Article
- Alterations in gene expression in the spinal cord of mice lacking Nfix.BMC research notes · 2020Article
- Common Regulatory Targets of NFIA, NFIX and NFIB during Postnatal Cerebellar Development.Cerebellum (London, England) · 2020Article
- Moving into shape: cell migration during the development and histogenesis of the cerebellum.Histochemistry and cell biology · 2018Review
- BDNF activates an NFI-dependent neurodevelopmental timing program by sequestering NFATc4.Molecular biology of the cell · 2018Article
- Transcriptional regulation of ependymal cell maturation within the postnatal brain.Neural development · 2018Article
- DNER and NFIA are expressed by developing and mature AII amacrine cells in the mouse retina.The Journal of comparative neurology · 2018Article
- Lkb1 regulates granule cell migration and cortical folding of the cerebellar cortex.Developmental biology · 2017Article
- Consensus Paper: Cerebellar Development.Cerebellum (London, England) · 2016Review
- Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition.eLife · 2016Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
A central question is how various stages of neuronal development are integrated as a differentiation program. Here we show that the nuclear factor I (NFI) family of transcriptional regulators is expressed and functions throughout the postmitotic development of cerebellar granule neurons (CGNs). Expression of an NFI dominant repressor in CGN cultures blocked axon outgrowth and dendrite formation and decreased CGN migration. Inhibition of NFI transactivation also disrupted extension and fasciculation of parallel fibers as well as CGN migration to the internal granule cell layer in cerebellar slices. In postnatal day 17 Nfia-deficient mice, parallel fibers were greatly diminished and disoriented, CGN dendrite formation was dramatically impaired, and migration from the external germinal layer (EGL) was retarded. Axonal marker expression also was disrupted within the EGL of embryonic day 18 Nfib-null mice. NFI regulation of axon extension was observed under conditions of homotypic cell contact, implicating cell surface proteins as downstream mediators of its actions in CGNs. Consistent with this, the cell adhesion molecules ephrin B1 and N-cadherin were identified as NFI gene targets in CGNs using inhibitor and Nfi mutant analysis as well as chromatin immunoprecipitation. Functional inhibition of ephrin B1 or N-cadherin interfered with CGN axon extension and guidance, migration, and dendritogenesis in cell culture as well as in situ. These studies define NFI as a key regulator of postmitotic CGN development, in particular of axon formation, dendritogenesis, and migratory behavior. Furthermore, they reveal how a single transcription factor family can control and integrate multiple aspects of neuronal differentiation through the regulation of cell adhesion molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.