ArticleJournal of clinical microbiology2007
Molecular typing of isolates of Rickettsia rickettsii by use of DNA sequencing of variable intergenic regions.
Article in Journal of clinical microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 66 citations in OpenAlex.
- Characterization of Hairpin Loops and Cruciforms Across 118,019 Genomes Spanning the Tree of Life.Genome biology and evolution · 2026Article
- Analysis of Rocky Mountain spotted fever cases in Northern Mexico reveals genetic variability of Rickettsia rickettsii and the different distribution of genotypes.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- Completed genomes forMicrobiology resource announcements · 2023Article
- Development and validation of a novel detection method forFrontiers in microbiology · 2023Article
- Procedure for spotted fever group Rickettsia isolation from limited clinical blood specimens.PLoS neglected tropical diseases · 2022Article
- Phylogenetic Differentiation of Rickettsia parkeri Reveals Broad Dispersal and Distinct Clustering within North American Strains.Microbiology spectrum · 2021Article
- Isolate-Dependent Differences in Clinical, Pathological, and Transcriptional Profiles followingInfection and immunity · 2021Article
- Comparative Analysis of Infection byPathogens (Basel, Switzerland) · 2020Article
- A Novel TaqMan Assay for Detection ofJournal of clinical microbiology · 2019Article
- Multistate Survey of American Dog Ticks (Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2019Article
- Fatal Rocky Mountain Spotted Fever along the United States-Mexico Border, 2013-2016.Emerging infectious diseases · 2017Article
- Vector competence of Amblyomma americanum (Acari: Ixodidae) for Rickettsia rickettsii.Ticks and tick-borne diseases · 2017Article
- Diversification of Orientia tsutsugamushi genotypes by intragenic recombination and their potential expansion in endemic areas.PLoS neglected tropical diseases · 2017Article
- Extremely Low Genomic Diversity of Rickettsia japonica Distributed in Japan.Genome biology and evolution · 2017Article
- Article
- The Eco-epidemiology of Pacific Coast Tick Fever in California.PLoS neglected tropical diseases · 2016Article
- Phylogeography of Rhipicephalus sanguineus sensu lato and its relationships with climatic factors.Experimental & applied acarology · 2016Article
- Rickettsia rickettsii in Amblyomma patinoi ticks, Colombia.Emerging infectious diseases · 2015Article
- Challenges posed by tick-borne rickettsiae: eco-epidemiology and public health implications.Frontiers in public health · 2015Review
- Genetic identification of rickettsial isolates from fatal cases of Brazilian spotted fever and comparison with Rickettsia rickettsii isolates from the American continents.Journal of clinical microbiology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever, is found throughout the Americas, where it is associated with different animal reservoirs and tick vectors. No molecular typing system currently exists to allow for the robust differentiation of isolates of R. rickettsii. Analysis of eight completed genome sequences of rickettsial species revealed a high degree of sequence conservation within the coding regions of chromosomes in the genus. Intergenic regions between coding sequences should be under less selective pressure to maintain this conservation and thus should exhibit greater nucleotide polymorphisms. Utilizing these polymorphisms, we developed a molecular typing system that allows for the genetic differentiation of isolates of R. rickettsii. This typing system was applied to a collection of 38 different isolates collected from humans, animals, and tick vectors from different geographic locations. Serotypes 364D, from Dermacentor occidentalis ticks, and Hlp, from Haemaphysalis leporispalustris ticks, appear to be distinct genotypes that may not belong to the species R. rickettsii. We were also able to differentiate 36 historical isolates of R. rickettsii into three different phylogenetic clades containing seven different genotypes. This differentiation correlated well, but not perfectly, with the geographic origin and likely tick vectors associated with the isolates. The few apparent typing discrepancies found suggest that the molecular ecology of R. rickettsii needs more investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.