ArticleBiochimica et biophysica acta2007
The ErbB4 receptor in fetal rat lung fibroblasts and epithelial type II cells.
Article in Biochimica et biophysica acta, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Novel cardiac biomarkers and multiple-marker approach in the early detection, prognosis, and risk stratification of cardiac diseases.World journal of cardiology · 2025Review
- Uncovering the prominent role of satellite cells in paravertebral muscle development and aging by single-nucleus RNA sequencing.Genes & diseases · 2023Article
- What is the identity of fibroblast-pneumocyte factor?Pediatric research · 2016Review
- Interdependent TTF1 - ErbB4 interactions are critical for surfactant protein-B homeostasis in primary mouse lung alveolar type II cells.Journal of cell communication and signaling · 2015Article
- Neuregulin-ErbB4 signaling in the developing lung alveolus: a brief review.Journal of cell communication and signaling · 2014Article
- Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactions.The Journal of biological chemistry · 2012Article
- Estrogen-induced upregulation of Sftpb requires transcriptional control of neuregulin receptor ErbB4 in mouse lung type II epithelial cells.Biochimica et biophysica acta · 2011Article
- Lipopolysaccharide-induced injury is more pronounced in fetal transgenic ErbB4-deleted lungs.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Neuregulin receptor ErbB4 functions as a transcriptional cofactor for the expression of surfactant protein B in the fetal lung.American journal of respiratory cell and molecular biology · 2011Article
- Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation.Biochimica et biophysica acta · 2011Article
- ErbB4 regulates the timely progression of late fetal lung development.Biochimica et biophysica acta · 2010Article
- The ERBB3 receptor in cancer and cancer gene therapy.Cancer gene therapy · 2008Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
ErbB receptors are important regulators of fetal organ development, including the fetal lung. They exhibit diversity in signaling potential, acting through homo- and heterodimers to cause different biological responses. We hypothesized that ErbB receptors show cell-specific and stimuli-specific activation, heterodimerization, and cellular localization patterns in fetal lung. We investigated this using immunoblotting, co-immunoprecipitation, and confocal microscopy in primary isolated E19 fetal rat lung fibroblasts and epithelial type II cells, stimulated with epidermal growth factor, transforming growth factor alpha, neuregulin 1beta, or treated with conditioned medium (CM) from the respective other cell type. Fetal type II cells expressed significantly more ErbB1, ErbB2, and ErbB3 protein than fibroblasts. ErbB4 was consistently identified by co-immunoprecipitation of all other ErbB receptors in both cell types independent of the treatments. Downregulation of ErbB4 in fibroblasts initiated cell-cell communication that stimulated surfactant phospholipid synthesis in type II cells. Confocal microscopy in type II cells revealed nuclear localization of all receptors, most prominently for ErbB4. Neuregulin treatment resulted in relocation to the extra-nuclear cytoplasmic region, which was distinct from fibroblast CM treatment which led to nuclear localization of ErbB4 and ErbB2, inducing co-localization of both receptors. We speculate that ErbB4 plays a prominent role in fetal lung mesenchyme-epithelial communication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.