ArticleBiochimica et biophysica acta2007
Probing the mechanism of FET3 repression by Izh2p overexpression.
Article in Biochimica et biophysica acta, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
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- Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2.PLoS biology · 2020Article
- Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.PLoS genetics · 2020Article
- A Saccharomyces cerevisiae assay system to investigate ligand/AdipoR1 interactions that lead to cellular signaling.PloS one · 2013Article
- Characterization and ligand identification of a membrane progesterone receptor in fungi: existence of a novel PAQR in Sporothrix schenckii.BMC microbiology · 2012Article
- Phylogenetic and preliminary phenotypic analysis of yeast PAQR receptors: potential antifungal targets.Journal of molecular evolution · 2011Article
- CREST--a large and diverse superfamily of putative transmembrane hydrolases.Biology direct · 2011Article
- Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.Nature medicine · 2011Article
- Antagonism of human adiponectin receptors and their membrane progesterone receptor paralogs by TNFalpha and a ceramidase inhibitor.Biochemistry · 2009Article
- Sphingolipids function as downstream effectors of a fungal PAQR.Molecular pharmacology · 2009Article
- Adiponectin identified as an agonist for PAQR3/RKTG using a yeast-based assay system.Journal of receptor and signal transduction research · 2009Article
- Article
- Dissecting the regulation of yeast genes by the osmotin receptor.Biochemical and biophysical research communications · 2008Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
We previously reported a role for the IZH2 gene product in metal ion metabolism. Subsequently, Izh2p was also identified as a member of the PAQR family of receptors and, more specifically, as the receptor for the plant protein osmotin. In this report, we investigate the effect of Izh2p on iron homeostasis. We show that overproduction of Izh2p prevents the iron-dependent induction of the Fet3p component of the high-affinity iron-uptake system and is deleterious for growth in iron-limited medium. We demonstrate that the effect of Izh2p requires cAMP-dependent kinase and AMP-dependent kinase and is not mediated by general inhibition of the Aft1p iron-responsive transcriptional activator. We also show that Izh2p-overproduction negatively regulates Nrg1p/Nrg2p- and Msn2p/Msn4p-dependent reporters. Furthermore, we show that the Nrg1p/Nrg2p and Msn2p/Msn4p pairs are epistatic to each other with respect to their effects on FET3 expression. Finally, we show that the mechanism by which PAQR receptors activate signal transduction pathways is likely to be conserved from yeast to humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.