ArticleEmerging infectious diseases2007
Levels of abnormal prion protein in deer and elk with chronic wasting disease.
Article in Emerging infectious diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Prions in Muscles of Cervids with Chronic Wasting Disease, Norway.Emerging infectious diseases · 2025Article
- New developments in prion disease research using genetically modified mouse models.Cell and tissue research · 2023Review
- Chronic wasting disease: a cervid prion infection looming to spillover.Veterinary research · 2021Review
- Article
- Chronic Wasting Disease (CWD) in Sami Reindeer Herding: The Socio-Political Dimension of an Epizootic in an Indigenous Context.Animals : an open access journal from MDPI · 2021Article
- Article
- Update on chronic wasting disease (CWD) III.EFSA journal. European Food Safety Authority · 2019Article
- Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Animal prion diseases: the risks to human health.Brain pathology (Zurich, Switzerland) · 2019Review
- Molecular Mechanisms of Chronic Wasting Disease Prion Propagation.Cold Spring Harbor perspectives in medicine · 2018Review
- Comparative analysis of prions in nervous and lymphoid tissues of chronic wasting disease-infected cervids.The Journal of general virology · 2018Article
- Scientific opinion on chronic wasting disease (II).EFSA journal. European Food Safety Authority · 2018Article
- Chronic wasting disease (CWD) in cervids.EFSA journal. European Food Safety Authority · 2017Article
- Prion amplification and hierarchical Bayesian modeling refine detection of prion infection.Scientific reports · 2015Article
- Article
- Experimental transmission of chronic wasting disease (CWD) from elk and white-tailed deer to fallow deer by intracerebral route: final report.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2011Article
- Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoring.PLoS pathogens · 2010Article
- Detection of sub-clinical CWD infection in conventional test-negative deer long after oral exposure to urine and feces from CWD+ deer.PloS one · 2009Article
- Susceptibilities of nonhuman primates to chronic wasting disease.Emerging infectious diseases · 2009Article
- Characteristics of 263K scrapie agent in multiple hamster species.Emerging infectious diseases · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic wasting disease (CWD) of deer and elk is a widespread health concern because its potential for crossspecies transmission is undetermined. CWD prevalence in wild elk is much lower than its prevalence in wild deer, and whether CWD-infected deer and elk differ in ability to infect other species is unknown. Because lymphoid tissues are important in the pathogenesis of some transmissible spongiform encephalopathies such as sheep scrapie, we investigated whether CWD-affected elk and deer differ in distribution or quantity of disease-associated prion protein (PrPres) in lymphoid tissues. Immunoblot quantification of PrPres from tonsil and retropharyngeal lymph nodes showed much higher levels of PrPres in deer than in elk. This difference correlated with the natural prevalence of CWD in these species and suggested that CWD-infected deer may be more likely than elk to transmit the disease to other cervids and have a greater potential to transmit CWD to noncervids.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.