ArticleEmerging infectious diseases2007
Effectiveness of neuraminidase inhibitors for preventing staff absenteeism during pandemic influenza.
Article in Emerging infectious diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic literature review on public health and healthcare resources for pandemic preparedness planning.BMC public health · 2024Pooled it
- Infectious disease transmission: survey of contacts between hospital-based healthcare workers and working adults from the general population.The Journal of hospital infection · 2018Article
- Trends in parameterization, economics and host behaviour in influenza pandemic modelling: a review and reporting protocol.Emerging themes in epidemiology · 2013Article
- Article
- Optimizing tactics for use of the U.S. antiviral strategic national stockpile for pandemic influenza.PloS one · 2011Article
- Article
- Risk factors for pandemic (H1N1) 2009 virus seroconversion among hospital staff, Singapore.Emerging infectious diseases · 2010Article
- Seroconversion and asymptomatic infections during oseltamivir prophylaxis against Influenza A H1N1 2009.BMC infectious diseases · 2010Article
- Optimizing tactics for use of the U.S. Antiviral Strategic National Stockpile for Pandemic (H1N1) Influenza, 2009.PLoS currents · 2009Article
- Pandemic influenza and excess intensive-care workload.Emerging infectious diseases · 2008Article
- Virtual epidemic in a virtual city: simulating the spread of influenza in a US metropolitan area.Translational research : the journal of laboratory and clinical medicine · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used a deterministic SEIR (susceptible-exposed-infectious-removed) meta-population model, together with scenario, sensitivity, and simulation analyses, to determine stockpiling strategies for neuraminidase inhibitors that would minimize absenteeism among healthcare workers. A pandemic with a basic reproductive number (R0) of 2.5 resulted in peak absenteeism of 10%. Treatment decreased peak absenteeism to 8%, while 8 weeks' prophylaxis reduced it to 2%. For pandemics with higher R0, peak absenteeism exceeded 20% occasionally and 6 weeks' prophylaxis reduced peak absenteeism by 75%. Insufficient duration of prophylaxis increased peak absenteeism compared with treatment only. Earlier pandemic detection and initiation of prophylaxis may render shorter prophylaxis durations ineffective. Eight weeks' prophylaxis substantially reduced peak absenteeism under a broad range of assumptions for severe pandemics (peak absenteeism > 10%). Small investments in treatment and prophylaxis, if adequate and timely, can reduce absenteeism among essential staff.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.