ArticleWorld journal of gastroenterology2007
H pylori iceA alleles are disease-specific virulence factors.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Association between vacA genotypes and the risk of duodenal ulcer: a meta-analysis.Molecular biology reports · 2014Pooled it
- Helicobacter pylori iceA, clinical outcomes, and correlation with cagA: a meta-analysis.PloS one · 2012Pooled it
- Global epidemiology ofMicrobiology spectrum · 2026Article
- Article
- Prevalence of SpecificJournal of clinical and diagnostic research : JCDR · 2017Article
- Diversity of Helicobacter pylori genotypes in Iranian patients with different gastroduodenal disorders.World journal of gastroenterology · 2013Article
- Molecular analysis of Helicobacter pylori virulent-associated genes in hepatobiliary patients.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2012Article
- Prevalence of genotypes in Helicobacter pyloriisolates from patients in eastern Turkey and the association of these genotypes with clinical outcome.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2012Article
- Molecular Basis of pathogenicity in Helicobacter pylori clinical isolates.Journal of clinical microbiology · 2010Article
- Clinical significance of Helicobacter pylori cagA and iceA genotype status.World journal of gastroenterology · 2010Article
- Prevalence of Helicobacter pylori vacA, cagA, iceA and oipA genotypes in Tunisian patients.Annals of clinical microbiology and antimicrobials · 2010Article
- Cofactor requirement of HpyAV restriction endonuclease.PloS one · 2010Article
- The association of vacA genotypes and Helicobacter pylori-related gastroduodenal diseases in the Middle East.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo characterize and compare genotype profiles of H pylori strains isolated from patients with chronic gastritis and duodenal ulcer in western part of Turkey.
methodsA total of 46 patients [30 chronic gastritis (CG) and 16 duodenal ulcer (DU)] who had undergone endoscopy because of dyspeptic complaints were studied. The antral biopsy specimens were evaluated for the presence of H pylori by rapid urease test and culture, and the genotype profiles were determined by real-time PCR.
resultsThe cagA gene was observed in 43 (93.5%) isolates. The vacA s1m2 genotype was the predominant subtype, found in 63.3% and 68.7% of isolates in patients with CG and DU, respectively. Twenty (66.6%) isolates from patients with CG were iceA2 positive while the iceA1 was predominant in those with DU (68.8%). In terms of the association of the iceA alleles to other genes, both alleles were significantly associated with the cagA vacA s1m2 genotype.
conclusionThe prevalent circulating genotypes in CG and DU were cagA vacA s1m2 iceA2 and cagA vacA s1m2 iceA1 genotype, respectively. It was found that cagA vacA s1m2 genotype seems to be common virulence factors in both CG and DU while iceA alleles show specificity for gastroduodenal pathologies in this study.
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