ArticleNeurochemical research2007
Lipid peroxidation scavengers prevent the carbonylation of cytoskeletal brain proteins induced by glutathione depletion.
Article in Neurochemical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- The effects of gamma glutamyl cysteinyl ethyl ester in traumatically brain injured rats post incident: insight into the role of glutathione elevation in oxidative stress.Frontiers in neuroscience · 2026Article
- MIND Diet Impact on Multiple Sclerosis Patients: Biochemical Changes after Nutritional Intervention.International journal of molecular sciences · 2024Article
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- Alzheimer's Disease: A Review of Pathology, Current Treatments, and the Potential Therapeutic Effect of Decreasing Oxidative Stress by Combined Vitamin D and l-Cysteine Supplementation.Antioxidants & redox signaling · 2024Review
- Inhibition of Protein and Lipid Oxidation in Ready-to-Eat Chicken Patties by aFoods (Basel, Switzerland) · 2021Article
- Mechanism of Protein Carbonylation in Glutathione-Depleted Rat Brain Slices.Neurochemical research · 2018Article
- Peroxiredoxins prevent oxidative stress during human sperm capacitation.Molecular human reproduction · 2017Article
- Article
- The pro-oxidant buthionine sulfoximine (BSO) reduces tumor growth of implanted Lewis lung carcinoma in mice associated with increased protein carbonyl, tubulin abundance, and aminopeptidase activity.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Different susceptibility of prefrontal cortex and hippocampus to oxidative stress following chronic social isolation stress.Molecular and cellular biochemistry · 2014Article
- Proteomic identification of carbonylated proteins in the kidney of trichloroethene-exposed MRL+/+ mice.Toxicology mechanisms and methods · 2014Article
- Traditional reactive carbonyl scavengers do not prevent the carbonylation of brain proteins induced by acute glutathione depletion.Free radical research · 2010Article
- Direct reaction of taurine with malondialdehyde: evidence for taurine as a scavenger of reactive carbonyl species.Redox report : communications in free radical research · 2010Article
- Phenolic compounds protect cultured hippocampal neurons against ethanol-withdrawal induced oxidative stress.International journal of molecular sciences · 2009Article
- Cytoskeletal protein carbonylation and degradation in experimental autoimmune encephalomyelitis.Journal of neurochemistry · 2008Article
- Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling.The Journal of physiology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In this study, we investigated the possible link between lipid peroxidation (LPO) and the formation of protein carbonyls (PCOs) during depletion of brain glutathione (GSH). To this end, rat brain slices were incubated with the GSH depletor diethyl maleate (DEM) in the absence or presence of classical LPO scavengers: trolox, caffeic acid phenethyl ester (CAPE), and butylated hydroxytoluene (BHT). All three scavengers reduced DEM-induced lipid oxidation and protein carbonylation, suggesting that intermediates/products of the LPO pathway such as lipid hydroperoxides, 4-hydroxynonenal and/or malondialdehyde are involved in the process. Additional in vitro experiments revealed that, among these products, lipid hydroperoxides are most likely responsible for protein oxidation. Interestingly, BHT prevented the carbonylation of cytoskeletal proteins but not that of soluble proteins, suggesting the existence of different mechanisms of PCO formation during GSH depletion. In pull-down experiments, beta-actin and alpha/beta-tubulin were identified as major carbonylation targets during GSH depletion, although other cytoskeletal proteins such as neurofilament proteins and glial fibrillary acidic protein were also carbonylated. These findings may be important in the context of neurological disorders that exhibit decreased GSH levels and increased protein carbonylation such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis.
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