ReviewEuropean journal of nuclear medicine and molecular imaging2007
Cardiovascular molecular imaging of apoptosis.
Review in European journal of nuclear medicine and molecular imaging, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Detection of apoptosis by [Annals of nuclear medicine · 2023Article
- Article
- Direct myocardial ischemia imaging with exercise ¹⁸FDG.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- A dual-labeled Annexin A5 is not suited for SPECT imaging of brain cell death in experimental murine stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- Noninvasive imaging of myocyte apoptosis following application of a stem cell-engineered delivery platform to acutely infarcted myocardium.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2013Article
- Imaging Myocardial Ischemia and Reperfusion Injury via Cy5.5-Annexin V.Nuclear medicine and molecular imaging · 2012Article
- Failure of annexin-based apoptosis imaging in the assessment of antiangiogenic therapy effects.EJNMMI research · 2011Article
- Visualization of cell death in mice with focal cerebral ischemia using fluorescent annexin A5, propidium iodide, and TUNEL staining.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Article
- MicroPET imaging of ketamine-induced neuronal apoptosis with radiolabeled DFNSH.Journal of neural transmission (Vienna, Austria : 1996) · 2011Article
- Imaging atherosclerosis and vulnerable plaque.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2010Review
- Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure.Circulation. Cardiovascular imaging · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMolecular imaging strives to visualise processes at the molecular and cellular level in vivo. Understanding these processes supports diagnosis and evaluation of therapeutic efficacy on an individual basis and thereby makes personalised medicine possible. APOPTOSIS AND MOLECULAR IMAGING: Apoptosis is a well-organised mode of cell suicide that plays a role in cardiovascular diseases (CVD). Apoptosis is associated with loss of cardiomyocytes following myocardial infarction, atherosclerotic plaque instability, congestive heart failure and allograft rejection of the transplanted heart. Thus, apoptosis constitutes an attractive target for molecular imaging of CVD. Our current knowledge about the molecular players and mechanisms underlying apoptosis offers a rich palette of potential molecular targets for molecular imaging. However, only a few have been successfully developed so far.
aimsThis review highlights aspects of the molecular machinery and biochemistry of apoptosis relevant to the development of molecular imaging probes. It surveys the role of apoptosis in four major areas of CVD and portrays the importance and future perspectives of apoptosis imaging. The annexin A5 imaging protocol is emphasised since it is the most advanced protocol to measure apoptosis in both preclinical and clinical studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.