ArticleMolecular and cellular biochemistry2007
Prostaglandin E2 enhances mitogen-activated protein kinase/Erk pathway in human cholangiocarcinoma cells: involvement of EP1 receptor, calcium and EGF receptors signaling.
Article in Molecular and cellular biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- lncRNA LINC00152 knockdown suppressed hepatic cancer biological activity.Archives of medical science : AMS · 2026Article
- PGE2 Potentiates Orai1-Mediated Calcium Entry Contributing to Peripheral Sensitization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Intrahepatic cholangiocarcinoma: Morpho-molecular pathology, tumor reactive microenvironment, and malignant progression.Advances in cancer research · 2021Review
- ErBb Family Proteins in Cholangiocarcinoma and Clinical Implications.Journal of clinical medicine · 2020Review
- New Horizons for Precision Medicine in Biliary Tract Cancers.Cancer discovery · 2017Review
- EGFR Signaling in Liver Diseases.International journal of molecular sciences · 2015Review
- Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line.The Journal of biological chemistry · 2015Article
- EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells.Biomolecules & therapeutics · 2015Article
- Prostacyclin regulates bone growth via the Epac/Rap1 pathway.Endocrinology · 2015Article
- Prostaglandin E2 stimulates β1-integrin expression in hepatocellular carcinoma through the EP1 receptor/PKC/NF-κB pathway.Scientific reports · 2014Article
- Prostaglandin E2 EP1 receptor antagonist improves motor deficits and rescues memory decline in R6/1 mouse model of Huntington's disease.Molecular neurobiology · 2014Article
- Upregulation of prostaglandin receptor EP1 expression involves its association with cyclooxygenase-2.PloS one · 2014Article
- Prostaglandin E2 receptor EP1 phosphorylate CREB and mediates MMP2 expression in human cholangiocarcinoma cells.Molecular and cellular biochemistry · 2013Article
- Regulation of the ligand-dependent activation of the epidermal growth factor receptor by calmodulin.The Journal of biological chemistry · 2012Article
- ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression.Cancer research · 2011Article
- HEF1 is a crucial mediator of the proliferative effects of prostaglandin E(2) on colon cancer cells.Cancer research · 2010Article
- Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma.World journal of gastroenterology · 2008Review
- Identification of prostaglandin E2 receptors mediating perinatal masculinization of adult sex behavior and neuroanatomical correlates.Developmental neurobiology · 2008Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
COX-2-derived PGE2 has been implicated in the development of various types of cancers. However, the exact mechanism of PGE2-induced cancer cell proliferation and survival is still unclear. In the current study, the mechanism underlying PGE2-enhanced Erk phosphorylation in human cholangiocarcinoma cells was determined. The intracellular concentration of calcium in three cholangiocarcinoma cell lines was measured using a laser confocal scanning microscope and the expression levels of Erk and EGFR phosphorylation were determined by Western blot analyses. The activation of EP1 receptors involved in PGE2-stimulated Erk activation and increasing the intracellular concentration of calcium was elucidated using selective EP1 receptor subtype antagonists and agonist. The intracellular calcium chelator, BAPTA-AM, was shown to block PGE2-induced Erk and EGFR phosphorylation. PGE2-induced Erk phosphorylation was abrogated by pretreatment with the EGF receptor kinase inhibitor, AG1478. Our findings suggest that in human cholangiocarcinoma cells, PGE2-enhanced phosphorylation of Erk is, at least in part, mediated through EP1 receptors and EGFR phosphorylation induced by increases in the intracellular concentration of calcium.
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