ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2008
Acute amphetamine exposure selectively desensitizes kappa-opioid receptors in the nucleus accumbens.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Kappa opioid receptors mediate an initial aversive component of paclitaxel-induced neuropathy.Psychopharmacology · 2020Article
- Chronic ethanol exposure increases inhibition of optically targeted phasic dopamine release in the nucleus accumbens core and medial shell ex vivo.Molecular and cellular neurosciences · 2017Article
- Naltrexone modulates dopamine release following chronic, but not acute amphetamine administration: a translational study.Translational psychiatry · 2017Article
- Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion.Scientific reports · 2017Article
- Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- The one-two punch of alcoholism: role of central amygdala dynorphins/kappa-opioid receptors.Biological psychiatry · 2014Article
- Pilocarpine-induced temporal lobe epilepsy in the rat is associated with increased dopamine neuron activity.The international journal of neuropsychopharmacology · 2012Article
- The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.Cellular and molecular life sciences : CMLS · 2012Review
- Nicotine withdrawal and kappa-opioid receptors.Psychopharmacology · 2010Article
- Methylphenidate and μ opioid receptor interactions: a pharmacological target for prevention of stimulant abuse.NeuropharmacologyArticle
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4 authors at 2 institutions in 1 country.
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Abstract
In the present study, we investigated the effects of psychostimulant exposure on kappa-opioid peptide (KOP) receptor signaling in the rat mesolimbic system. A single subcutaneous (s.c.) injection of amphetamine (2.5 mg/kg) reduced the KOP receptor-mediated inhibition of glutamate release in the nucleus accumbens shell, as a consequence of KOP receptor desensitization. This effect was blocked by dopamine (DA) receptor antagonists or the nonselective opioid antagonist, naltrexone (1 mg/kg, s.c.), and mimicked by the KOP receptor agonists U69593 (0.32 mg/kg, s.c.) and dynorphin (1 microM), indicating that an amphetamine-induced release of dynorphin is producing a long-lasting desensitization of the KOP receptor. Despite the fact that amphetamine also increases dynorphin release in the ventral tegmental area (VTA), KOP receptor function in this region was not affected by amphetamine; there was no difference in the KOP receptor-mediated change in firing rate or resting membrane potential measured in VTA neurons from saline- or amphetamine-treated animals. This study demonstrates that amphetamine can produce regionally selective adaptations in KOP receptor signaling, which may, in turn, alter the effects of subsequent drug exposure.
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