ArticlePediatric diabetes2007
Study design of the Trial to Reduce IDDM in the Genetically at Risk (TRIGR).
Article in Pediatric diabetes, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00179777 (TRIGR - Trial to Reduce IDDM in the Genetically at Risk), which is not on this map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TRIGR - Trial to Reduce IDDM in the Genetically at Risk
Who cites it
36 citing papers in PubMed, 110 citations in OpenAlex.
- Regional differences in milk and complementary feeding patterns in infants participating in an international nutritional type 1 diabetes prevention trial.Maternal & child nutrition · 2017Trial
- Expansion of CD4+CD25+FOXP3+ regulatory T cells in infants of mothers with type 1 diabetes.Pediatric diabetes · 2012Trial
- The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up.Diabetologia · 2011Trial
- Dietary intervention in infancy and later signs of beta-cell autoimmunity.The New England journal of medicine · 2010Trial
- Breastfeeding patterns of mothers with type 1 diabetes: results from an infant feeding trial.Diabetes/metabolism research and reviews · 2010Trial
- Evolving epigenomics of immune cells at single-nucleus resolution in children en route to type 1 diabetes.Nature communications · 2026Article
- Single-cell RNA-seq analysis of longitudinal CD4Genome medicine · 2025Article
- Beta cell function in the early stages of type 1 diabetes: still a long way ahead of us.Pediatric endocrinology, diabetes, and metabolism · 2023Article
- Neglected Facts onInternational journal of molecular sciences · 2022Review
- Dietary compliance in a randomized double-blind infant feeding trial during infancy aiming at prevention of type 1 diabetes.Food science & nutrition · 2021Article
- Growth and development of islet autoimmunity and type 1 diabetes in children genetically at risk.Diabetologia · 2021Article
- Association of diabetes-related autoantibodies with the incidence of asthma, eczema and allergic rhinitis in the TRIGR randomised clinical trial.Diabetologia · 2020Article
- Milk feeding and first complementary foods during the first year of life in the TEDDY study.Maternal & child nutrition · 2018Article
- Article
- Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes.Diabetologia · 2014Article
- Use of vitamin D supplements during infancy in an international feeding trial.Public health nutrition · 2014Article
- Large-scale prospective T cell function assays in shipped, unfrozen blood samples: experiences from the multicenter TRIGR trial.Clinical and vaccine immunology : CVI · 2014Article
- The use of intermediate endpoints in the design of type 1 diabetes prevention trials.Diabetologia · 2013Article
- Pathogenesis of type 1 diabetes: lessons from natural history studies of high-risk individuals.Annals of the New York Academy of Sciences · 2013Review
- Primary and secondary prevention of Type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The hypothesis for this study is that weaning to an extensively hydrolyzed infant formula will decrease the incidence of type 1 diabetes (T1D), as it does in all relevant animal models for the disease. This will be tested in children who carry risk-associated human leukocyte antigen genotypes and have a first-degree relative with T1D. The trial will use a double-blind, prospective, placebo-controlled intervention protocol, comparing casein hydrolysate with a conventional cow's milk (CM)-based formula. A secondary aim is to determine relationships between CM antibodies, a measure of CM exposure, and diabetes-associated autoantibodies. To achieve an 80% power for the detection of a 40% intervention-induced difference in the development of autoantibodies and subsequent diabetes, the study requires 2032 subjects. A multicenter, international, collaborative effort is necessary to achieve recruitment targets. A collaborative international study group of 78 clinical centers in 15 countries has therefore been assembled for this purpose.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.