ArticlePLoS biology2007
Principles of genome evolution in the Drosophila melanogaster species group.
Article in PLoS biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
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Who cites it
118 citing papers in PubMed.
- Transposable elements as drivers of genome evolution in Drosophila virilis.Nucleic acids research · 2026Article
- Telomere-to-telomere genome assembly of the Dipteran Bactrocera dorsalis from a single individual.Nature communications · 2025Article
- Putting Structural Variants Into Practice: The Role of Chromosomal Inversions in the Management of Marine Environments.Molecular ecology · 2025Review
- Comparative Genomics of the Testacea Group of Drosophila Reveals Introgression and Variation in Chromosome Size and Structure.Genome biology and evolution · 2025Article
- Genome Architecture and Speciation in Plants and Animals.Molecular ecology · 2025Review
- Chromosomal Inversions Mediated by Tandem Insertions of Transposable Elements.Genome biology and evolution · 2025Article
- Chromosomal Inversions in Chromosome U ofInsects · 2025Article
- Analysis of 30 chromosome-level Drosophila genome assemblies reveals dynamic evolution of centromeric satellite repeats.Genome biology · 2025Article
- The Influence of Chromosomal Inversions on Genetic Variation and Clinal Patterns in Genomic Data of Drosophila melanogaster.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana).Molecular ecology · 2024Article
- The origin and maintenance of supergenes contributing to ecological adaptation in Atlantic herring.Nature communications · 2024Article
- Genomics of natural populations: gene conversion events reveal selected genes within the inversions of Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2024Article
- Two Nested Inversions in the X Chromosome Differentiate the Dominant Malaria Vectors in Europe,Insects · 2024Article
- Demonstration of in vivo engineered tandem duplications of varying sizes using CRISPR and recombinases in Drosophila melanogaster.G3 (Bethesda, Md.) · 2023Article
- Genome assemblies and comparison of two Neotropical spiral gingers: Costus pulverulentus and C. lasius.The Journal of heredity · 2023Article
- Implications of the Niche Partitioning and Coexistence of Two Resident Parasitoids forInsects · 2023Article
- Evaluating impacts of syntenic block detection strategies on rearrangement phylogeny using Mycobacterium tuberculosis isolates.Bioinformatics (Oxford, England) · 2023Article
- Getting higher on rugged landscapes: Inversion mutations open access to fitter adaptive peaks in NK fitness landscapes.PLoS computational biology · 2022Article
- The relevance of chromatin architecture to genome rearrangements inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Meiotic Chromosomal Abnormality Detected in a Heterozygote ofFrontiers in plant science · 2022Article
58 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
That closely related species often differ by chromosomal inversions was discovered by Sturtevant and Plunkett in 1926. Our knowledge of how these inversions originate is still very limited, although a prevailing view is that they are facilitated by ectopic recombination events between inverted repetitive sequences. The availability of genome sequences of related species now allows us to study in detail the mechanisms that generate interspecific inversions. We have analyzed the breakpoint regions of the 29 inversions that differentiate the chromosomes of Drosophila melanogaster and two closely related species, D. simulans and D. yakuba, and reconstructed the molecular events that underlie their origin. Experimental and computational analysis revealed that the breakpoint regions of 59% of the inversions (17/29) are associated with inverted duplications of genes or other nonrepetitive sequences. In only two cases do we find evidence for inverted repetitive sequences in inversion breakpoints. We propose that the presence of inverted duplications associated with inversion breakpoint regions is the result of staggered breaks, either isochromatid or chromatid, and that this, rather than ectopic exchange between inverted repetitive sequences, is the prevalent mechanism for the generation of inversions in the melanogaster species group. Outgroup analysis also revealed evidence for widespread breakpoint recycling. Lastly, we have found that expression domains in D. melanogaster may be disrupted in D. yakuba, bringing into question their potential adaptive significance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.