ArticleRheumatology international2007
Pro-inflammatory cellular immune response in Behçet's disease.
Article in Rheumatology international, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Genetic variations of IL-12B, IL-12Rβ1, IL-12Rβ2 in Behcet's disease and VKH syndrome.PloS one · 2014Trial
- Pan-Immune-Inflammation Value Predicts Disease Activity and Ocular Involvement in Behçet's Disease: A Case-Control Study.Mediterranean journal of rheumatology · 2026Article
- Novel inflammatory biomarkers for discriminating vascular involvement in Behçet's syndrome: evaluating SII, SIRI, and NPAR.Biomarkers in medicine · 2025Article
- Behçet's Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2024Review
- Heat Shock Proteins in Behçet SyndromeBalkan medical journal · 2023Review
- Association of long non-coding RNAs NEAT1, and MALAT1 expression and pathogenesis of Behçet's disease among Egyptian patients.Saudi journal of biological sciences · 2022Article
- Cascade of immune mechanism and consequences of inflammatory disorders.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2021Review
- Autoimmune vertigo: an update on vestibular disorders associated with autoimmune mechanisms.Immunologic research · 2018Review
- Cytokine, C-Reactive Protein, and Heat Shock Protein mRNA Expression Levels in Patients with Active Behçet's Uveitis.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Possible association of proinflammatory cytokines including IL1β and TNFα with enhanced Th17 cell differentiation in patients with Behcet's disease.Clinical rheumatology · 2016Article
- Morbus Behçet - a rare disease in Central Europe.Archives of medical science : AMS · 2015Article
- IL12Rβ1: the cytokine receptor that we used to know.Cytokine · 2015Review
- Helicobacter pylori and skin autoimmune diseases.World journal of gastroenterology · 2014Review
- A New Diagnostic Way for Behcet's Disease: Skin Prick with Self-Saliva.Genetics research international · 2014Review
- Expression of regulatory receptors on γδ T cells and their cytokine production in Behcet's disease.Arthritis research & therapy · 2013Article
- Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria.Frontiers in immunology · 2013Article
- Excessive CD4+ T cells co-expressing interleukin-17 and interferon-γ in patients with Behçet's disease.Clinical and experimental immunology · 2012Article
- Potential Infectious Etiology of Behçet's Disease.Pathology research international · 2012Article
- Histopathological Evaluation of Behçet's Disease and Identification of New Skin Lesions.Pathology research international · 2012Article
- [Autoinflammatory diseases as cause of wound healing defects].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2011Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several proteins are investigated as candidate auto-antigens in the pathogenesis of Behçet's disease (BD). This study aimed to screen the cellular responses to auto-antigen (alphaB-crystallin, alphaBC), and microorganism (Streptococcus sangius KTH-1 BES-1 protein) derived peptides as well as to isopentenyl pyrophosphate (IPP). Peripheral blood mononuclear cells (PBMC) from 22 BD patients and 22 healthy controls (HC) were stimulated in vitro with alphaBC, BES-1 peptides, IPP and PPD and induced proliferation as well as the secreted interleukin (IL)-12 and interferon (IFN)-gamma production levels were measured. We did not observe any significant difference in cellular proliferation between BD patients and HC. Induction of IL-12 secretion with alphaBC was stronger in BD patients (P = 0.04) and in the disease subgroup with uveitis (P = 0.027) compared the HC. When responses to PPD were compared, proliferation of PMBC was lower (P = 0.03), whereas IL-12 secretion was higher in BD (P = 0.04) as well as in patients under colchicum treatment (P = 0.04) and with vascular involvement (P = 0.006) compared to HC. BES-1(373-385 )peptide induced also higher IL-12 productions by PBMC of BD patients (P = 0.017) and of patients with uveitis (P = 0.013). Finally, IPP stimulated higher IL-12 secretions from PBMC in BD patients (P = 0.035) and in patients with (P = 0.02) or without (P = 0.017) uveitis or arthritis (P = 0.04), under colchicum treatment (P = 0.01) or not receiving any immunosuppressive treatment (P = 0.007) compared to HC. These results suggest a more prominent pro-inflammatory cytokine secretion from PBMC in BD patients compared to HC in response to various antigens including alphaBC protein, BES-1(373-385), IPP and PPD.
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Registered trials
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