ArticleDiabetologia2007
Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis.
Article in Diabetologia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03038620 (Impact of Liraglutide 3.0 on Body Fat Distribution, Visceral Adiposity, and Cardiometabolic Risk Markers In Overweight and Obese Adults at High Risk for Cardiovascular Disease), which is not on this map. Cited by 216 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Liraglutide 3.0 on Body Fat Distribution, Visceral Adiposity, and Cardiometabolic Risk Markers In Overweight and Obese Adults at High Risk for Cardiovascular Disease
Who cites it
216 citing papers in PubMed, 1 synthesis or guideline pooled it, 357 citations in OpenAlex.
- Fat Cell Size: Measurement Methods, Pathophysiological Origins, and Relationships With Metabolic Dysregulations.Endocrine reviews · 2022Pooled it
- Weight gain leads to greater adverse metabolic responses in South Asian compared with white European men: the GlasVEGAS study.Nature metabolism · 2024Trial
- Adipocyte size, adipose tissue calories, and circulating adipokines, before and after diet-induced weight loss in humans.Endocrine · 2024Trial
- A higher proportion of small adipocytes is associated with increased visceral and ectopic lipid accumulation during weight gain in response to overfeeding in men.International journal of obesity (2005) · 2022Trial
- Adipose depot-specific effects of 16 weeks of pioglitazone on in vivo adipogenesis in women with obesity: a randomised controlled trial.Diabetologia · 2021Trial
- Effect of conjugated estrogens and bazedoxifene on glucose, energy and lipid metabolism in obese postmenopausal women.European journal of endocrinology · 2020Trial
- Exercise training improves adipose tissue metabolism and vasculature regardless of baseline glucose tolerance and sex.BMJ open diabetes research & care · 2020Trial
- Dietary weight loss in insulin-resistant non-obese humans: Metabolic benefits and relationship to adipose cell size.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2019Trial
- The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men.International journal of obesity (2005) · 2014Trial
- Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity.Diabetologia · 2010Trial
- Metabolic changes following a 1-year diet and exercise intervention in patients with type 2 diabetes.Diabetes · 2010Trial
- Human fecal transplantation from stunted children promotes metabolic dysfunction in mice fed with a high-fat and high-fructose corn syrup diet.Gut microbes · 2026Article
- Metabolic heterogeneity of obesity.Nature medicine · 2026Review
- Transient activation of ciliary CCR2 signaling promotes the initiation of adipogenesis.Nature communications · 2026Article
- Visceral, Not Abdominal Subcutaneous, Fat Cell Size Associates with Metabolic Dysfunction-Associated Liver Disease in Severe Obesity.Obesity facts · 2026Article
- Impact of time-restricted feeding on metabolic health and adipose tissue metabolism in aged female mice with high-fat diet-induced obesity.The Journal of physiology · 2026Article
- Metabolic health and cardiovascular risk among Cameroonian adults with and without obesity.PLOS global public health · 2026Article
- Article
- Influence of Weight Loss and Weight Regain on Adipose Tissue Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Adipose cellularity as a measurement of long-term changes in body weight: a Swedish cohort study spanning 1988-2016.EClinicalMedicine · 2025Article
156 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
aims/hypothesisThe biological mechanism by which obesity predisposes to insulin resistance is unclear. One hypothesis is that larger adipose cells disturb metabolism via increased lipolysis. While studies have demonstrated that cell size increases in proportion to BMI, it has not been clearly shown that adipose cell size, independent of BMI, is associated with insulin resistance. The aim of this study was to test this widely held assumption by comparing adipose cell size distribution in 28 equally obese, otherwise healthy individuals who represented extreme ends of the spectrum of insulin sensitivity, as defined by the modified insulin suppression test. SUBJECTS AND
methodsSubcutaneous periumbilical adipose tissue biopsy samples were fixed in osmium tetroxide and passed through the Beckman Coulter Multisizer to obtain cell size distributions. Insulin sensitivity was quantified by the modified insulin suppression test. Quantitative real-time PCR for adipose cell differentiation genes was performed for 11 subjects.
resultsAll individuals exhibited a bimodal cell size distribution. Contrary to expectations, the mean diameter of the larger cells was not significantly different between the insulin-sensitive and insulin-resistant individuals. Moreover, insulin resistance was associated with a higher ratio of small to large cells (1.66 +/- 1.03 vs 0.94 +/- 0.50, p = 0.01). Similar cell size distributions were observed for isolated adipose cells. The real-time PCR results showed two- to threefold lower expression of genes encoding markers of adipose cell differentiation (peroxisome proliferator-activated receptor gamma1 [PPARgamma1], PPARgamma2, GLUT4, adiponectin, sterol receptor element binding protein 1c) in insulin-resistant compared with insulin-sensitive individuals. CONCLUSIONS/
interpretationThese results suggest that after controlling for obesity, insulin resistance is associated with an expanded population of small adipose cells and decreased expression of differentiation markers, suggesting that impairment in adipose cell differentiation may contribute to obesity-associated insulin resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.