ArticleThe Journal of clinical investigation2007
Sizing up sialic acid in glomerular disease.
Article in The Journal of clinical investigation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Phase 1 Study of Oral N-Acetylmannosamine in Primary Podocytopathies.Kidney international reports · 2026Article
- Spatial composition and turnover of the main molecules in the adult glomerular basement membrane.Tissue barriers · 2023Review
- Changes in the Expression of Renal Brush Border MembraneBiomolecules · 2021Article
- Elevated plasma free sialic acid levels in individuals with reduced glomerular filtration rates.Kidney360 · 2020Article
- Rationale and Design for a Phase 1 Study ofKidney international reports · 2019Article
- Biological roles of glycans.Glycobiology · 2017Review
- Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases.The Journal of biological chemistry · 2014Article
- Oral monosaccharide therapies to reverse renal and muscle hyposialylation in a mouse model of GNE myopathy.Molecular genetics and metabolism · 2012Article
- The Gne M712T mouse as a model for human glomerulopathy.The American journal of pathology · 2012Article
- Sepsis induces albuminuria and alterations in the glomerular filtration barrier: a morphofunctional study in the rat.Critical care (London, England) · 2011Article
- Hereditary inclusion body myopathy: a decade of progress.Biochimica et biophysica acta · 2009Review
- Preclinical assessment of wt GNE gene plasmid for management of hereditary inclusion body myopathy 2 (HIBM2).Gene regulation and systems biology · 2008Article
- Proteinuria: is it all in the foot?The Journal of clinical investigation · 2007Article
Corrections and comments
- Comment on
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new study by Galeano and colleagues in this issue of the JCI reports the first glomerular disease caused by a genetic defect in sialic acid biosynthesis (see the related article beginning on page 1585). Mice that harbor mutations in the Gne/Mnk gene produce lower amounts of sialic acid, suffer from hematuria, proteinuria, and structural defects in the glomerulus and die within days after birth. Remarkably, the lesion can be reversed through dietary addition of N-acetylmannosamine, a sialic acid precursor, raising the intriguing possibility that this approach might have therapeutic benefit in patients with glomerular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.