Evidence map›Paper›PMID 17548582›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2007

The innate immune system in allograft rejection and tolerance.

David F LaRosa, Adeeb H Rahman, Laurence A Turka

Abstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Effect of dapagliflozin on rat liver ischemia-reperfusion injury.Veterinary research forum : an international quarterly journal · 2026
    Article
  5. Review
  6. Review
  7. Adenosine triphosphate-mediated signaling of P2X7 receptors controls donor extracellular vesicle release and major histocompatibility complex cross-decoration after allotransplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  8. Review
  9. Review
  10. Animal models for transplant immunology: bridging bench to bedside.Clinical transplantation and research · 2024
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Dendritic cells in liver transplantation immune response.Frontiers in cell and developmental biology · 2023
    Review
  17. Article
  18. Review
  19. Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David F LaRosaDepartment of Medicine, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA. david.larosa@uphs.upenn.edu
Adeeb H Rahman
Laurence A Turka

Funding

TRAINING IN PULMONARY IMMUNOLOGYT32HL007586 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 1985 to 2025
$8.8M
Expression and function of the TLRs on T cellsR01AI062789 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI TURKA, LAURENCE A · 2006 to 2010
$1.9M
NHLBI NIH HHS T32 HL 007586NHLBI NIH HHS T32 HL007586NIAID NIH HHS R01 AI 062789NIAID NIH HHS R01 AI062789
6 · The paper itself

Abstract

As T cells alone are both necessary and sufficient for the rejection of virtually all allogeneic tissues, much of transplantation immunology has focused on cells of the adaptive immune system. During the past decade, advances in our understanding of innate responses to pathogen-associated molecules have spurred a "rediscovery" of innate immunity. Fueled by this, an increasing body of literature has emerged in which the role of the innate immune system in allograft rejection and tolerance has been examined more closely. This review will give an overview of recent studies and emerging concepts of how the cellular components of the innate immune system participate in the immune response to solid organ transplantation. These important studies highlight the complex interplay between diverse cells of the immune response and provide the basis for optimal strategies of tolerance induction.

Indexed as

Immunity, InnateOrgan TransplantationTransplantation ToleranceAnimalsGraft RejectionHumansImmunosuppression TherapyMiceReceptors, Pattern RecognitionT-LymphocytesTransplantation, HomologousReceptors, Pattern Recognition

Identifiers

PMID17548582
PMCPMC2840045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.