ArticleThe Journal of cell biology2007
A novel cell response triggered by interphase centromere structural instability.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Coilin and SUMOylation influence PARP1 dynamics and the DNA damage response.Journal of cell science · 2025Article
- Reshuffling Overcrowded Milieu: Stress-Induced Reorganization of the Eukaryotic Membrane-Less Organelles.Sub-cellular biochemistry · 2025Review
- Finding new roles of classic biomolecular condensates in the nucleus: Lessons from fission yeast.Cell insight · 2024Review
- The fission yeast ortholog of Coilin, Mug174, forms Cajal body-like nuclear condensates and is essential for cellular quiescence.Nucleic acids research · 2024Article
- Reorganization of Cell Compartmentalization Induced by Stress.Biomolecules · 2022Review
- Chromatin-mediated epigenetic regulation of HSV-1 transcription as a potential target in antiviral therapy.Antiviral research · 2021Review
- Heat and chilling stress induce nucleolus morphological changes.Journal of plant research · 2019Article
- Towards an understanding of regulating Cajal body activity by protein modification.RNA biology · 2017Review
- Article
- Nuclear accumulation of annexin A2 contributes to chromosomal instability by coilin-mediated centromere damage.Oncogene · 2015Article
- Article
- Coilin association with Box C/D scaRNA suggests a direct role for the Cajal body marker protein in scaRNP biogenesis.Biology open · 2014Article
- Signals controlling Cajal body assembly and function.The international journal of biochemistry & cell biology · 2013Review
- Coilin displays differential affinity for specific RNAs in vivo and is linked to telomerase RNA biogenesis.Journal of molecular biology · 2013Article
- Article
- Coilin levels modulate cell cycle progression and γH2AX levels in etoposide treated U2OS cells.FEBS letters · 2012Article
- In vitro RNase and nucleic acid binding activities implicate coilin in U snRNA processing.PloS one · 2012Article
- Centromere architecture breakdown induced by the viral E3 ubiquitin ligase ICP0 protein of herpes simplex virus type 1.PloS one · 2012Article
- HSV-1 genome subnuclear positioning and associations with host-cell PML-NBs and centromeres regulate LAT locus transcription during latency in neurons.PLoS pathogens · 2012Article
- Coilin participates in the suppression of RNA polymerase I in response to cisplatin-induced DNA damage.Molecular biology of the cell · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Interphase centromeres are crucial domains for the proper assembly of kinetochores at the onset of mitosis. However, it is not known whether the centromere structure is under tight control during interphase. This study uses the peculiar property of the infected cell protein 0 of herpes simplex virus type 1 to induce centromeric structural damage, revealing a novel cell response triggered by centromere destabilization. It involves centromeric accumulation of the Cajal body-associated coilin and fibrillarin as well as the survival motor neuron proteins. The response, which we have termed interphase centromere damage response (iCDR), was observed in all tested human and mouse cells, indicative of a conserved mechanism. Knockdown cells for several constitutive centromere proteins have shown that the loss of centromeric protein B provokes the centromeric accumulation of coilin. We propose that the iCDR is part of a novel safeguard mechanism that is dedicated to maintaining interphase centromeres compatible with the correct assembly of kinetochores, microtubule binding, and completion of mitosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.