ArticleInfection and immunity2007
Inactivation of traP has no effect on the agr quorum-sensing system or virulence of Staphylococcus aureus.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Deciphering agr quorum sensing in Staphylococcus aureus: insights and therapeutic prospects.Molecular biology reports · 2024Review
- Proteomic Profiles of Staphylococcus aureus Strains Associated with Subclinical Bovine Mastitis.Current microbiology · 2022Article
- Non-Antimicrobial Adjuvant Strategies to Tackle Biofilm-RelatedAntibiotics (Basel, Switzerland) · 2021Review
- Staphylococcal Biofilm on the Surface of Catheters: Electron Microscopy Evaluation of the Inhibition of Biofilm Growth by RNAIII Inhibiting Peptide.Antibiotics (Basel, Switzerland) · 2021Article
- Review
- Red-Brown Pigmentation ofMicroorganisms · 2019Article
- Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective.Journal of medicinal chemistry · 2013Article
- Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides.Nucleic acids research · 2013Article
- Identification of an intracellular M17 family leucine aminopeptidase that is required for virulence in Staphylococcus aureus.Microbes and infection · 2012Article
- Structure of the signal transduction protein TRAP (target of RNAIII-activating protein).Acta crystallographica. Section F, Structural biology and crystallization communications · 2012Article
- The stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression.PLoS pathogens · 2012Article
- NsaRS is a cell-envelope-stress-sensing two-component system of Staphylococcus aureus.Microbiology (Reading, England) · 2011Article
- Medicinal chemistry as a conduit for the modulation of quorum sensing.Journal of medicinal chemistry · 2010Article
- A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulation.The Journal of infectious diseases · 2009Article
- Staphylococcal biofilms.Current topics in microbiology and immunology · 2008Review
- Identification and characterization of sigma, a novel component of the Staphylococcus aureus stress and virulence responses.PloS one · 2008Article
- Infection control by antibody disruption of bacterial quorum sensing signaling.Chemistry & biology · 2007Article
- A nonsense mutation in agrA accounts for the defect in agr expression and the avirulence of Staphylococcus aureus 8325-4 traP::kan.Infection and immunity · 2007Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The success of Staphylococcus aureus as a pathogen can largely be attributed to the plethora of genetic regulators encoded within its genome that temporally regulate its arsenal of virulence determinants throughout its virulence lifestyle. Arguably the most important of these is the two-component, quorum-sensing system agr. Over the last decade, the controversial presence of a second quorum-sensing system (the TRAP system) has been proposed, and it has been mooted to function as the master regulator of virulence in S. aureus by modulating agr. Mutants defective in TRAP are reported to be devoid of agr expression, lacking in hemolytic activity, essentially deficient in the secretion of virulence determinants, and avirulent in infection models. A number of research groups have questioned the validity of the TRAP findings in recent years; however, a thorough and independent analysis of its role in S. aureus physiology and pathogenesis has not been forthcoming. Therefore, we have undertaken such an analysis of the TRAP locus of S. aureus. We found that a traP mutant was equally hemolytic as the wild-type strain. Furthermore, transcriptional profiling found no alterations in the traP mutant in expression levels of agr or in expression levels of multiple agr-regulated genes (hla, sspA, and spa). Analysis of secreted and surface proteins of the traP mutant revealed no deviation in comparison to the parent. Finally, analysis conducted using a murine model of S. aureus septic arthritis revealed that, in contrast to an agr mutant, the traP mutant was just as virulent as the wild-type strain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.