ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2007
Duplicated gelsolin family genes in zebrafish: a novel scinderin-like gene (scinla) encodes the major corneal crystallin.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- A temporal single cell transcriptome atlas of zebrafish anterior segment development.Scientific reports · 2023Article
- Article
- Zebrafish Cacna1fa is required for cone photoreceptor function and synaptic ribbon formation.Human molecular genetics · 2014Article
- Ocular surface development and gene expression.Journal of ophthalmology · 2013Article
- Disruption of blastomeric F-actin: a potential early biomarker of developmental toxicity in zebrafish.Molecular and cellular biochemistry · 2011Review
- Update on the aldehyde dehydrogenase gene (ALDH) superfamily.Human genomics · 2011Article
- Physiological expression of lens α-, β-, and γ-crystallins in murine and human corneas.Molecular vision · 2010Article
- Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress.The Journal of biological chemistry · 2010Article
- The zebrafish lens proteome during development and aging.Molecular vision · 2009Article
- Differential expression patterns and developmental roles of duplicated scinderin-like genes in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- The transparent lens and cornea in the mouse and zebra fish eye.Seminars in cell & developmental biology · 2008Review
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
We have previously identified a gelsolin-like protein (C/L-gelsolin) as a corneal crystallin in zebrafish. Here we show by phylogenetic analysis that there are at least six genes encoding gelsolin-like proteins based on their gelsolin domains in zebrafish: gsna and gsnb group with the vertebrate gelsolin gene, scina and scinb group with the scinderin (adseverin) gene, and scinla (C/L-gelsolin) and scinlb are novel scinderin-like genes. RT-PCR showed that scinla, scinlb, and gsnb are preferentially expressed in the adult cornea whereas gsna is expressed to a similar extent in cornea, lens, brain, and heart; scina and scinb expression were detectable only in whole zebrafish and not in these adult tissues. Quantitative RT-PCR and 2-dimensional polyacrylamide gel electrophoresis followed by MALDI/TOF mass spectroscopy confirmed high expression of beta-actin and scinla, moderate expression of scinlb, and very low expression of gsna and gsnb in the cornea. Finally, transgenic zebrafish carrying a green fluorescent protein reporter transgene driven by a 4 kb scinla promoter fragment showed expression in the cornea, snout, dorsal fin, and tail fin of 3-day-old zebrafish larvae. Our data suggest that scinla and scinlb are diverged paralogs of the vertebrate scinderin gene and show that scinla encodes the zebrafish corneal crystallin previously called C/L-gelsolin.
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