ArticleBiochemical and biophysical research communications2007
Serotonin induces selective cleavage of the PKA RI subunit but not RII subunit in Aplysia neurons.
Article in Biochemical and biophysical research communications, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Regulation of Translation by PKA Signaling Pathway.International journal of molecular sciences · 2026Review
- Role of proteasome-dependent protein degradation in long-term operant memory in Aplysia.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Local synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Critical role for protein kinase A in the acquisition of gregarious behavior in the desert locust.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- PKC differentially translocates during spaced and massed training in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Evolutionary conservation of the signaling proteins upstream of cyclic AMP-dependent kinase and protein kinase C in gastropod mollusks.Brain, behavior and evolution · 2009Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
PKA type I and type II are activated in Aplysia neurons by stimulation with serotonin (5-HT), which causes long-term facilitation (LTF). The proteolysis of the regulatory subunit (R) is thought important for the persistent activation of PKA, which is necessary to produce LTF. In this study, we report that the type I regulatory subunit (RI) and type II regulatory subunit (RII) are differentially regulated by proteolytic cleavage. RI, but not RII, was selectively cleaved after 5-HT treatment for 2h in Aplysia neurons. Interestingly, the proteasome inhibitor MG132 inhibited the cleavage of RI caused by 5-HT treatment in Aplysia neuron. Besides extracts from Aplysia ganglia treated with 5-HT cleaved (35)S-labeled RI synthesized in vitro, but not (35)S-labeled RII. This suggests that 5-HT induces the activation state of RI-specific proteolytic cleavage.
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Registered trials
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