ReviewCurrent HIV/AIDS reports2007
Adherence-resistance relationships to combination HIV antiretroviral therapy.
Review in Current HIV/AIDS reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00608569 (International Trial of Modified Directly Observed Therapy Versus Self-Administered Therapy for Participants With First Virologic Failure on a Non-Nucleoside Reverse Transcriptase Inhibitor-Containing Antiretroviral Regimen), which is not on this map. Cited by 102 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
International Trial of Modified Directly Observed Therapy Versus Self-Administered Therapy for Participants With First Virologic Failure on a Non-Nucleoside Reverse Transcriptase Inhibitor-Containing Antiretroviral Regimen
Who cites it
102 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Enroling and retaining human immunodeficiency virus (HIV) patients in their care: A metasynthesis of qualitative studies.International journal of nursing studies · 2016Pooled it
- A systematic review of antiretroviral adherence interventions for HIV-infected people who use drugs.Current HIV/AIDS reports · 2012Pooled it
- Trial
- Phone-delivered mindfulness training to promote medication adherence and reduce sexual risk behavior among persons living with HIV: Design and methods.Contemporary clinical trials · 2017Trial
- Individualized texting for adherence building (iTAB): improving antiretroviral dose timing among HIV-infected persons with co-occurring bipolar disorder.AIDS and behavior · 2015Trial
- Brief behavioral self-regulation counseling for HIV treatment adherence delivered by cell phone: an initial test of concept trial.AIDS patient care and STDs · 2011Trial
- Integrated behavioral intervention to improve HIV/AIDS treatment adherence and reduce HIV transmission.American journal of public health · 2011Trial
- Antiretroviral therapy adherence among patients living with HIV/AIDS in Thailand.Nursing & health sciences · 2010Trial
- Monthly unannounced pill counts for monitoring HIV treatment adherence: tests for self-monitoring and reactivity effects.HIV clinical trialsTrial
- Critical level of food insecurity and nonadherence to antiretroviral therapy among adults living with HIV.Public health action · 2026Article
- Predictors of treatment-emergent resistance to dolutegravir.The lancet. HIV · 2025Review
- Overcoming challenges in the economic evaluation of interventions to optimise antibiotic use.Communications medicine · 2024Review
- LSTM-driven drug design using SELFIES for target-focused de novo generation of HIV-1 protease inhibitor candidates for AIDS treatment.PloS one · 2024Article
- Review
- The risk of drug resistance during long-acting antimicrobial therapy.Proceedings. Biological sciences · 2022Article
- Adherence to HIV Antiretroviral Therapy Among Pregnant and Breastfeeding Women, Non-Pregnant Women, and Men in Burkina Faso: Nationwide Analysis 2019-2020.Patient preference and adherence · 2022Article
- Factors associated with the risk of upper respiratory tract bacterial infections among HIV-positive patients.PloS one · 2022Article
- Article
- Substance Use-Related Intentional Nonadherence to Antiretroviral Therapy Among Young Adults Living with HIV.AIDS patient care and STDs · 2022Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Early views on the relationship between adherence and resistance postulated a bell-shaped relationship that balanced selective drug pressure and improved viral suppression along a continuum of adherence. Although this conceptual relationship remains valid, recent data suggest that each regimen class may have different adherence-resistance relationships. These regimen-specific relationships are a function of the capacities of resistant virus to replicate at different levels of drug exposure, which are largely, but not entirely, determined by the impact of mutations on susceptibility of the virus and the impact of the mutations on the inherent ability of the virus to replicate efficiently. Specific patterns of adherence, such as treatment discontinuations, may influence adherence-resistance relationship to combination regimens comprised of medications with differing half-lives. Host genomics that alters antiretroviral drug distribution and metabolism may also impact adherence-resistance relationships. Optimal antiretroviral regimens should be constructed such that there is little overlap in the window of adherence that selects for antiretroviral drug resistance.
Indexed as
Identifiers
17547827What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.