ArticleObesity surgery2007
Parathyroid hormone and bone marker levels in patients with morbid obesity before and after biliopancreatic diversion.
Article in Obesity surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- SAGES guideline for clinical application of laparoscopic bariatric surgery.Surgical endoscopy · 2008Guideline
- The role of serum osteoprotegerin and receptor-activator of nuclear factor-κB ligand in metabolic bone disease of women after obesity surgery.Journal of bone and mineral metabolism · 2016Trial
- Bone mass decreases in morbidly obese women after long limb-biliopancreatic diversion and marked weight loss without secondary hyperparathyroidism. A physiological adaptation to weight loss?Obesity surgery · 2009Trial
- Increase of osteopontin plasma concentrations after bariatric surgery independent from inflammation and insulin resistance.Obesity surgery · 2009Trial
- The Predictive Role of Parathyroid Hormone for Nonalcoholic Fatty Liver Disease following Bariatric Surgery.Journal of nutrition and metabolism · 2022Article
- Secondary Hyperparathyroidism in Patients with Biliopancreatic Diversion After 10 Years of Follow-up, and Relationship with Vitamin D and Serum Calcium.Obesity surgery · 2019Article
- Bone Health following Bariatric Surgery: Implications for Management Strategies to Attenuate Bone Loss.Advances in nutrition (Bethesda, Md.) · 2018Review
- Predictive Factors of Secondary Normocalcemic Hyperparathyroidism after Roux-en-Y Gastric Bypass.International journal of endocrinology · 2018Article
- Vitamin D alteration associated with obesity and bariatric surgery.Experimental biology and medicine (Maywood, N.J.) · 2017Review
- Serum Bioavailable Vitamin D Concentrations and Bone Mineral Density in Women After Obesity Surgery.Obesity surgery · 2016Article
- Parathyroid Hormone Levels May Predict Nonalcoholic Steatohepatitis in Morbidly Obese Patients.Hepatitis monthly · 2015Article
- Calcium metabolism, vitamin D and bone mineral density after bariatric surgery.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Observational
- Bone metabolism after bariatric surgery.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Review
- Bone loss after bariatric surgery: causes, consequences, and management.The lancet. Diabetes & endocrinology · 2014Article
- Increased PTH and 1.25(OH)(2)D levels associated with increased markers of bone turnover following bariatric surgery.Obesity (Silver Spring, Md.) · 2011Article
- Effect of a single 'megadose' intramuscular vitamin D (600,000 IU) injection on vitamin D concentrations and bone mineral density following biliopancreatic diversion surgery.Obesity surgery · 2010Article
- Chronic increase of bone turnover markers after biliopancreatic diversion is related to secondary hyperparathyroidism and weight loss. Relation with bone mineral density.Obesity surgery · 2010Article
- Article
- Clinical application of laparoscopic bariatric surgery: an evidence-based review.Surgical endoscopy · 2009Review
- The bone-adipose axis in obesity and weight loss.Obesity surgery · 2008Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundScopinaro biliopancreatic diversion (BPD) is associated with malabsorption of calcium and vitamin D, which manifests as a secondary hyperparathyroidism (SHP) and may lead to osteopenia.
methods96 morbidly obese patients were studied (age 19-60 years, 23 men and 73 women, with mean initial BMI 53) following intervention by Scopinaro BPD. The change in iPTH levels, urine DPD, Pyrilinks-D of DPC and serum CTx were studied at 0, 3, 6, 12, 18 and 24 months after surgery. Postoperatively, they were given supplements of calcium and vitamin D3. The control group consisted of 67 non-obese women and 10 men.
resultsThe iPTH levels gradually increased after BPD, with a substantial difference compared to presurgery levels at month 6. In spite of the calcium and vitamin D supplements, 77% of the patients with presurgery SHP did maintain high levels of iPTH after 2 years. The percentage of SHP among the patients with normal pre-surgery iPTH was 58%. The basal figures of DPD/cre were significantly higher than in the control group, 9.06 (4.6-13.5) nM/mMcre vs 3.9 (2.8-5.6) in men and 6.75 (5.4-7.9) vs 7.67 (3.3-11.6) in women, but not CTx, 0.24 (0.02-0.89) vs 0.22 (0.07-0.55). After the operation, there was a noticeable increase which persisted at 2 years. There was a lack of correlation between the levels of iPTH and the bone resorption markers, i.e. the first ones decreased from month 6 in men and from month 12 in women, while the levels of iPTH continued to increase.
conclusionIn obese patients, we found no correlation between iPTH levels and BMI. Supplements of calcium and vitamin D did not prevent the appearance of SHP following BPD. The patients with high pre-surgery iPTH levels have a higher risk of malabsorption of calcium and vitamin D. Following malabsorptive bariatric surgery, there is an increase in bone resorption, which results in DPD and CTx increase. Those markers do not correlate with iPTH, and this may suggest that there is a phenomenon of bone reshaping parallel to the loss of weight.
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