ArticleDigestive diseases and sciences2007
A polymorphism of microRNA 27a genome region is associated with the development of gastric mucosal atrophy in Japanese male subjects.
Article in Digestive diseases and sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Pooled it
- Shedding Light on the Molecular Diversities of miRNA in Cancer- an Exquisite Mini Review.Molecular biotechnology · 2025Review
- Factors Influencing the Degree of Gastric Atrophy inMicroorganisms · 2024Article
- The Single-Nucleotide Polymorphism of miR-27aEvidence-based complementary and alternative medicine : eCAM · 2022Article
- MiR-27a rs895819 is involved in increased atrophic gastritis risk, improved gastric cancer prognosis and negative interaction with Helicobacter pylori.Scientific reports · 2017Article
- Non-coding RNAs and cancer.International journal of molecular sciences · 2013Review
- Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1 in the gastric epithelium.BMC gastroenterology · 2013Article
- Genetic polymorphisms of miR-146a and miR-27a, H. pylori infection, and risk of gastric lesions in a Chinese population.PloS one · 2013Article
- Polymorphism in pre-miR-30c contributes to gastric cancer risk in a Chinese population.Medical oncology (Northwood, London, England) · 2012Article
- miRNAs in precancerous lesions of the gastrointestinal tract.World journal of gastroenterology · 2011Review
- Review
- Hsa-mir-27a genetic variant contributes to gastric cancer susceptibility through affecting miR-27a and target gene expression.Cancer science · 2010Article
- Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases.Molecular cancer · 2010Review
- Down-regulation of miR-27a might reverse multidrug resistance of esophageal squamous cell carcinoma.Digestive diseases and sciences · 2010Article
- Article
- Patrocles: a database of polymorphic miRNA-mediated gene regulation in vertebrates.Nucleic acids research · 2010Article
- SNPs in human miRNA genes affect biogenesis and function.RNA (New York, N.Y.) · 2009Article
- MicroRNA polymorphisms: a giant leap towards personalized medicine.Personalized medicine · 2009Article
- MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine.Pharmacogenomics · 2009Review
- Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes.RNA biologyArticle
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noncoding microRNAs regulate the expression of various mRNAs. We attempted to clarify the relationship between miR-27a genome polymorphism and chronic gastritis. The study was performed in 179 patients with no evidence of gastric malignancy. The severity of histologic chronic gastritis was classified according to the updated Sydney system. The frequency of miR-27a G allele was 34.6%. Although the frequencies of miR-27a G allele were increased in subjects with peptic ulcer or severe mucosal atrophy, no significant differences were seen. The miR-27a polymorphism showed an interaction with gender in relation to gastric mucosal atrophy (P=.090). In only male subjects, the miR-27a polymorphism was associated with the gastric mucosal atrophy (P=.039) and both atrophy and metaplasia scores in G/G group were significantly higher than those in the other groups. The miR-27a genome region polymorphism may be an important definitive factor to develop the gastric mucosal atrophy in Japanese male subjects.
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