Evidence map›Paper›PMID 17546465›Full record

ArticleHuman genetics2007

Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation.

Guillaume Lettre, Johannah L Butler, Kristin G Ardlie, Joel N Hirschhorn

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 54 citations in OpenAlex.

  1. A Genome-Wide Pharmacogenetic Study of Growth Hormone Responsiveness.The Journal of clinical endocrinology and metabolism · 2020
    Observational
  2. A descriptive study on selected growth parameters and growth hormone receptor gene in healthy young adults from the American Midwest.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2018
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Epigenetic heredity of human height.Physiological reports · 2014
    Article
  8. Article
  9. Towards identification of molecular mechanisms of short stature.International journal of pediatric endocrinology · 2013
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Genome-wide association study of height and body mass index in Australian twin families.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2010
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Guillaume LettreProgram in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Seven Cambridge Center, Cambridge, MA 02142, USA.
Johannah L Butler
Kristin G Ardlie
Joel N Hirschhorn
Broad Institute · USMassachusetts Institute of Technology · US

Funding

PHS HHS N01-25195
6 · The paper itself

Abstract

Stature (adult height) is one of the most heritable human traits, yet few genes, if any, have been convincingly associated with adult height variation in the general population. Here, we selected 150 tag SNPs from eight candidate genes in the growth hormone (GH)/insulin-like growth factor-1 (IGF1) axis (GHR, GHRH, GHRHR, IGF1, IGFALS, IGFBP3, JAK2, STAT5B), and genotyped them in approximately 2,200 individuals ascertained for short or tall stature. Nominally significant tag SNPs were then tested in three additional replication cohorts, including a family-based panel to rule out spurious associations owing to population stratification. Across the four height cohorts (N = 6,075 individuals), we did not observe any consistent associations between stature and common variants (> or =5% minor allele frequency) in these eight genes, including a common deletion of the growth hormone receptor gene exon 3. Tests of epistatic interactions between these genes did not yield any results beyond those expected by chance. Although we have not tested all genes in the GH/IGF1 axis, our results indicate that common variation in these GH/IGF1 axis genes is not a major determinant of stature, and suggest that if common variation contributes to adult height variation in the general population, the variants are in other, possibly unanticipated genes.

Indexed as

Genetic VariationBase SequenceBody HeightCarrier ProteinsComputational BiologyExonsFemaleGenotypeGlycoproteinsGrowth Hormone-Releasing HormoneHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IJanus Kinase 2MaleCarrier ProteinsGlycoproteinsGrowth Hormone-Releasing HormoneIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3insulin-like growth factor binding protein, acid labile subunitInsulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IJAK2 protein, humanJanus Kinase 2Receptors, NeuropeptideReceptors, Pituitary Hormone-Regulating Hormonesomatotropin-binding proteinsomatotropin releasing hormone receptorSTAT5B protein, humanSTAT5 Transcription Factor

Identifiers

PMID17546465
OpenAlexW2005280867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.