Trial reportBMJ (Clinical research ed.)2007
Long term results of compression therapy alone versus compression plus surgery in chronic venous ulceration (ESCHAR): randomised controlled trial.
Trial report in BMJ (Clinical research ed.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04714749 (Feasibility and Tolerance Study for the Treatment of Varicose Ulcers by Cyanoacrylate Glue), which is not on this map. Cited by 58 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility and Tolerance Study for the Treatment of Varicose Ulcers by Cyanoacrylate Glue
Who cites it
58 citing papers in PubMed, 11 syntheses or guidelines pooled it, 424 citations in OpenAlex.
- Automated devices for identifying peripheral arterial disease in people with leg ulceration: an evidence synthesis and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2024Pooled it
- Endovenous ablation for venous leg ulcers.The Cochrane database of systematic reviews · 2023Pooled it
- Medical compression therapy of the extremities with medical compression stockings (MCS), phlebological compression bandages (PCB), and medical adaptive compression systems (MAC) : S2k guideline of the German Phlebology Society (DGP) in cooperation with the following professional associations: DDG, DGA, DGG, GDL, DGL, BVP.Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2021Guideline
- [Medical compression therapy of the extremities with medical compression stockings (MCS), phlebological compression bandages (PCB), and medical adaptive compression systems (MAC) : S2k guideline of the German Phlebology Society (DGP) in cooperation with the following professional associations: DDG, DGA, DGG, GDL, DGL, BVP. German version].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2021Guideline
- Review of adjustable velcro wrap devices for venous ulceration.International wound journal · 2019Pooled it
- Compression Stockings for the Prevention of Venous Leg Ulcer Recurrence: A Health Technology Assessment.Ontario health technology assessment series · 2019Pooled it
- A 'test and treat' strategy for elevated wound protease activity for healing in venous leg ulcers.The Cochrane database of systematic reviews · 2016Pooled it
- Negative pressure wound therapy for treating leg ulcers.The Cochrane database of systematic reviews · 2015Pooled it
- Endovenous thermal ablation for healing venous ulcers and preventing recurrence.The Cochrane database of systematic reviews · 2013Pooled it
- Venous leg ulcers.BMJ clinical evidence · 2011Pooled it
- Venous leg ulcers.BMJ clinical evidence · 2008Pooled it
- Axial Ablation versus Terminal Interruption of the Reflux Source (AAVTIRS): A Randomised Controlled Trial.Vascular and endovascular surgery · 2024Trial
- Axial ablation versus terminal interruption of the reflux source (AAVTIRS): a randomised controlled trial.Trials · 2022Trial
- Supervised exercise training as an adjunct therapy for venous leg ulcers: a randomized controlled feasibility trial.The British journal of dermatology · 2018Trial
- Aspirin for Venous Ulcers: Randomised Trial (AVURT): study protocol for a randomised controlled trial.Trials · 2015Trial
- Randomised controlled trial comparing European standard class 1 to class 2 compression stockings for ulcer recurrence and patient compliance.International wound journal · 2014Trial
- Hydrogels in the Management of Peripheral Venous Disease: Bridging Material Design and Clinical Evidence.Gels (Basel, Switzerland) · 2026Review
- Health Outcomes Led by Advanced Practice Nurses in Patients With Chronic Wounds: A Scoping Review.Journal of clinical nursing · 2026Article
- Outcomes of iliofemoral venous stenting in women with venous ulcers.Journal of vascular surgery. Venous and lymphatic disorders · 2026Article
- Clinical outcomes and prognostic determinants of dehydrated human amnion/chorion membrane for refractory venous leg ulcers.Journal of vascular surgery. Venous and lymphatic disorders · 2026Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether recurrence of leg ulcers may be prevented by surgical correction of superficial venous reflux in addition to compression.
designRandomised controlled trial.
settingSpecialist nurse led leg ulcer clinics in three UK vascular centres.
participants500 patients (500 legs) with open or recently healed leg ulcers and superficial venous reflux.
interventionsCompression alone or compression plus saphenous surgery.
main outcome measuresPrimary outcomes were ulcer healing and ulcer recurrence. The secondary outcome was ulcer free time.
resultsUlcer healing rates at three years were 89% for the compression group and 93% for the compression plus surgery group (P=0.73, log rank test). Rates of ulcer recurrence at four years were 56% for the compression group and 31% for the compression plus surgery group (P<0.01). For patients with isolated superficial reflux, recurrence rates at four years were 51% for the compression group and 27% for the compress plus surgery group (P<0.01). For patients who had superficial with segmental deep reflux, recurrence rates at three years were 52% for the compression group and 24% for the compression plus surgery group (P=0.04). For patients with superficial and total deep reflux, recurrence rates at three years were 46% for the compression group and 32% for the compression plus surgery group (P=0.33). Patients in the compression plus surgery group experienced a greater proportion of ulcer free time after three years compared with patients in the compression group (78% v 71%; P=0.007, Mann-Whitney U test).
conclusionSurgical correction of superficial venous reflux in addition to compression bandaging does not improve ulcer healing but reduces the recurrence of ulcers at four years and results in a greater proportion of ulcer free time.
trial registrationCurrent Controlled Trials ISRCTN07549334 [controlled-trials.com].
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.