ArticleDNA repair2007
Synergistic action of the Saccharomyces cerevisiae homologous recombination factors Rad54 and Rad51 in chromatin remodeling.
Article in DNA repair, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Break-induced replication: unraveling each step.Trends in genetics : TIG · 2022Review
- Repression of a large number of genes requires interplay between homologous recombination and HIRA.Nucleic acids research · 2021Article
- The Tyrosyl-DNA Phosphodiesterase 1β (Tdp1β) Gene Discloses an Early Response to Abiotic Stresses.Genes · 2017Article
- Review
- DNA repair mechanisms and their biological roles in the malaria parasite Plasmodium falciparum.Microbiology and molecular biology reviews : MMBR · 2014Review
- Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA.Nucleic acids research · 2014Article
- Investigations of homologous recombination pathways and their regulation.The Yale journal of biology and medicine · 2013Review
- Functions of the Snf2/Swi2 family Rad54 motor protein in homologous recombination.Biochimica et biophysica acta · 2011Review
- Coordinated protein and DNA remodeling by human HLTF on stalled replication fork.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Regulation of Rad51 function by phosphorylation.EMBO reports · 2011Article
- Rad54, the motor of homologous recombination.DNA repair · 2010Review
- An archaeal Rad54 protein remodels DNA and stimulates DNA strand exchange by RadA.Nucleic acids research · 2009Article
- Filament formation and robust strand exchange activities of the rice DMC1A and DMC1B proteins.Nucleic acids research · 2008Article
- ATP-dependent chromatin remodeling by the Saccharomyces cerevisiae homologous recombination factor Rdh54.The Journal of biological chemistry · 2008Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Rad54, a member of the Swi2/Snf2 protein family, works in concert with the RecA-like recombinase Rad51 during the early and late stages of homologous recombination. Rad51 markedly enhances the activities of Rad54, including the induction of topological changes in DNA and the remodeling of chromatin structure. Reciprocally, Rad54 promotes Rad51-mediated DNA strand invasion with either naked or chromatinized DNA. Here, using various Saccharomyces cerevisiae rad51 and rad54 mutant proteins, mechanistic aspects of Rad54/Rad51-mediated chromatin remodeling are defined. Disruption of the Rad51-Rad54 complex leads to a marked attenuation of chromatin remodeling activity. Moreover, we present evidence that assembly of the Rad51 presynaptic filament represents an obligatory step in the enhancement of the chromatin remodeling reaction. Interestingly, we find a specific interaction of the N-terminal tail of histone H3 with Rad54 and show that the H3 tail interaction domain resides within the amino terminus of Rad54. These results suggest that Rad54-mediated chromatin remodeling coincides with DNA homology search by the Rad51 presynaptic filament and that this process is facilitated by an interaction of Rad54 with histone H3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.