ArticleNeurobiology of learning and memory2007
Learning and memory deficits in mice lacking protease activated receptor-1.
Article in Neurobiology of learning and memory, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses.Glia · 2024Article
- Inhibition of protease-activated receptor 1 (PAR1) ameliorates cognitive performance and synaptic plasticity impairments in animal model of Alzheimer's diseases.Psychopharmacology · 2021Article
- Role of Thrombin in Central Nervous System Injury and Disease.Biomolecules · 2021Review
- Role of the protease-activated receptor 1 in regulating the function of glial cells within central and peripheral nervous system.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Astrocytes and the Warning Signs of Intracerebral Hemorrhagic Stroke.Neural plasticity · 2018Review
- Protease Activated Receptor 2 (PAR2) Induces Long-Term Depression in the Hippocampus through Transient Receptor Potential Vanilloid 4 (TRPV4).Frontiers in molecular neuroscience · 2017Article
- Novel pharmaceutical treatments for minimal traumatic brain injury and evaluation of animal models and methodologies supporting their development.Journal of neuroscience methods · 2016Review
- Thrombin induces ischemic LTP (iLTP): implications for synaptic plasticity in the acute phase of ischemic stroke.Scientific reports · 2015Article
- PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Thrombin regulation of synaptic transmission and plasticity: implications for health and disease.Frontiers in cellular neuroscience · 2015Review
- Regulation of neuronal plasticity and fear by a dynamic change in PAR1-G protein coupling in the amygdala.Molecular psychiatry · 2013Article
- Treating seizures and epilepsy with anticoagulants?Frontiers in cellular neuroscience · 2013Article
- Protease-activated receptor-1 modulates hippocampal memory formation and synaptic plasticity.Journal of neurochemistry · 2013Article
- A histological and functional study on hippocampal formation of normal and diabetic rats.F1000Research · 2013Article
- Serine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behavior.Brain research · 2011Review
- Activation of protease activated receptor 1 increases the excitability of the dentate granule neurons of hippocampus.Molecular brain · 2011Article
- Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase-activated receptor-2.British journal of pharmacology · 2011Article
- Neuronal protease-activated receptor 1 drives synaptic retrograde signaling mediated by the endocannabinoid 2-arachidonoylglycerol.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
- Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines.Journal of neurochemistry · 2008Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The roles of serine proteases and protease activated receptors have been extensively studied in coagulation, wound healing, inflammation, and neurodegeneration. More recently, serine proteases have been suggested to influence synaptic plasticity. In this context, we examined the role of protease activated receptor 1 (PAR1), which is activated following proteolytic cleavage by thrombin and plasmin, in emotionally motivated learning. We were particularly interested in PAR1 because its activation enhances the function of NMDA receptors, which are required for some forms of synaptic plasticity. We examined several baseline behavioral measures, including locomotor activity, expression of anxiety-like behavior, motor task acquisition, nociceptive responses, and startle responses in C57Bl/6 mice in which the PAR1 receptor has been genetically deleted. In addition, we evaluated learning and memory in these mice using two memory tasks, passive avoidance and cued fear-conditioning. Whereas locomotion, pain response, startle, and measures of baseline anxiety were largely unaffected by PAR1 removal, PAR1-/- animals showed significant deficits in a passive avoidance task and in cued fear conditioning. These data suggest that PAR1 may play an important role in emotionally motivated learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.