ArticleCellular signalling2007
Multiple proteins mediate IQGAP1-stimulated cell migration.
Article in Cellular signalling, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- The Antipsychotic Drug Haldol Modulates IQGAP1-Signaling and Inhibits Cell Proliferation in Triple Negative Breast Cancer Cell Lines.microPublication biology · 2023Article
- IQGAP1 causes choroidal neovascularization by sustaining VEGFR2-mediated Rac1 activation.Angiogenesis · 2020Article
- Pleiotropic Roles of Calmodulin in the Regulation of KRas and Rac1 GTPases: Functional Diversity in Health and Disease.International journal of molecular sciences · 2020Review
- The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and Metastasis.International journal of molecular sciences · 2020Review
- Over-expression of IQGAP1 indicates poor prognosis in head and neck squamous cell carcinoma.Journal of molecular histology · 2018Article
- Calreticulin inhibits inflammation-induced osteoclastogenesis and bone resorption.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Article
- Proteomic Characterization Reveals a Molecular Portrait of Nasopharyngeal Carcinoma Differentiation.Journal of Cancer · 2017Article
- Shoc2-tranduced ERK1/2 motility signals--Novel insights from functional genomics.Cellular signalling · 2016Article
- Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration.The Journal of biological chemistry · 2012Article
- IQGAP1: a regulator of intracellular spacetime relativity.Journal of immunology (Baltimore, Md. : 1950) · 2012Review
- Salmonella enterica serotype Typhimurium usurps the scaffold protein IQGAP1 to manipulate Rac1 and MAPK signalling.The Biochemical journal · 2011Article
- Anchored protein kinase A recruitment of active Rac GTPase.The Journal of biological chemistry · 2011Article
- IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton.FEBS letters · 2011Review
- IQGAP1 is a novel CXCR2-interacting protein and essential component of the "chemosynapse".PloS one · 2011Article
- NMR structure of the calponin homology domain of human IQGAP1 and its implications for the actin recognition mode.Journal of biomolecular NMR · 2010Article
- IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation.Experimental & molecular medicine · 2010Article
- The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1.The EMBO journal · 2010Article
- IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis.FEBS letters · 2009Review
- Phospholipase D-mediated activation of IQGAP1 through Rac1 regulates hyperoxia-induced p47phox translocation and reactive oxygen species generation in lung endothelial cells.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cell migration, a highly complex physiological phenomenon that requires the co-ordinated and tightly regulated function of several proteins, is mediated by a number of signalling pathways. Elucidation of the molecular mechanisms of cell migration impacts our comprehension of numerous cell functions, ranging from development and immune surveillance to angiogenesis and metastasis. The scaffold protein IQGAP1, which binds multiple proteins and regulates their functions, promotes cell motility. Many of the IQGAP1 binding proteins have been implicated in cell migration. In this study, we employed a multifaceted strategy to identify proteins that contribute to IQGAP1-stimulated cell migration. Using specific IQGAP1 point mutant constructs, an interaction with actin was shown to be essential for IQGAP1 to increase cell migration. In contrast, eliminating the binding of Ca(2+)/calmodulin, but not Ca(2+)-free calmodulin, augmented the ability of IQGAP1 to stimulate cell migration. Consistent with these findings, selective inhibition of calmodulin function at the plasma membrane with a specific peptide inhibitor enhanced cell migration mediated by IQGAP1. Interestingly, immunofluorescence staining and confocal microscopy suggest that localization of Cdc42 at the leading edge is not necessary for maximal migration of epithelial cells. Coupled with the observations that Cdc42 and Rac1 contribute to IQGAP1-stimulated cell migration, these data suggest that IQGAP1 serves as a junction to integrate multiple signalling molecules to facilitate cell migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.