Evidence map›Paper›PMID 17544024›Full record

ReviewJournal of vascular surgery2007

The chemokine system in arteriogenesis and hind limb ischemia.

Paula K Shireman

Open access · greenAbstract readReview
In one paragraph

Review in Journal of vascular surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 130 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Estrogen-related receptor α is involved in angiogenesis and skeletal muscle revascularization in hindlimb ischemia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. NFAT5 promotes arteriogenesis via MCP-1-dependent monocyte recruitment.Journal of cellular and molecular medicine · 2020
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Paula K ShiremanSouth Texas Veterans Health Care System, Department of Surgery, Sam and Ann Barshop Institute for Longevity and Aging Studies, the University of Texas Health Science Center, San Antonio, TX, USA. Shireman@UTHSCSA.edu
South Texas Veterans Health Care System · US

Funding

CHEMOKINES AND IMMUNE CELLS IN HIND LIMB ISCHEMIAR01HL074236 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHIREMAN, PAULA K · 2003 to 2011
$3.0M
The Chemokine System in Collateral Artery FormationK08HL070158 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHIREMAN, PAULA K · 2002 to 2006
$645k
Chemokines and Immune Cells in Hind Limb IschemiaR56HL074236 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SHIREMAN, PAULA K · 2007 to 2007
$365k
NHLBI NIH HHS HL070158NHLBI NIH HHS HL074236NHLBI NIH HHS K08 HL070158NHLBI NIH HHS R01 HL074236NHLBI NIH HHS R56 HL074236
6 · The paper itself

Abstract

Chemokines (chemotactic cytokines) are important in the recruitment of leukocytes to injured tissues and, as such, play a pivotal role in arteriogenesis and the tissue response to ischemia. Hind limb ischemia represents a complex model with arteriogenesis (collateral artery formation) occurring in tissues with normal perfusion while areas exhibiting ischemic necrosis undergo angiogenesis and skeletal muscle regeneration; monocytes and macrophages play an important role in all three of these processes. In addition to leukocyte trafficking, chemokines are produced by and chemokine receptors are present on diverse cell types, including myoblasts, endothelial, and smooth muscle cells. Thus, the chemokine system may have direct effects as well as inflammatory-mediated effects on arteriogenesis, angiogenesis, and skeletal muscle regeneration. This article reviews the complexity of the hind limb ischemia model and the role of the chemokine system in arteriogenesis and the tissue response to ischemia. Special emphasis will be placed on the roles of monocytes/macrophages and CCL2/monocyte chemotactic protein-1 (MCP-1) in these processes.

Indexed as

Neovascularization, PhysiologicRegenerationAnimalsArteriesChemokine CCL2ChemokinesChemokines, CX3CDisease Models, AnimalHindlimbInflammationIschemiaMacrophagesMiceMonocytesMuscle, SkeletalReceptors, ChemokineCcl2 protein, mouseChemokine CCL2ChemokinesChemokines, CX3CReceptors, Chemokine

Identifiers

PMID17544024
PMCPMC2680944
OpenAlexW2064202159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.