ArticleNucleic acids research1991
Interaction of DNA-binding proteins with a milk protein gene promoter in vitro: identification of a mammary gland-specific factor.
Article in Nucleic acids research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 133 citations in OpenAlex.
- A Comparative Review of the Extrinsic and Intrinsic Factors Regulating Lactose Synthesis.Journal of mammary gland biology and neoplasia · 2021Review
- Coregulation of genetic programs by the transcription factors NFIB and STAT5.Molecular endocrinology (Baltimore, Md.) · 2014Article
- The spectrum of STAT functions in mammary gland development.JAK-STAT · 2012Review
- Polymorphisms of beta-lactoglobulin promoter region in three Sicilian goat breeds.Molecular biology reports · 2012Article
- Study of polymorphisms in the promoter region of ovine β-lactoglobulin gene and phylogenetic analysis among the Valle del Belice breed and other sheep breeds considered as ancestors.Molecular biology reports · 2012Article
- Protein profile and alpha-lactalbumin concentration in the milk of standard and transgenic goats expressing recombinant human butyrylcholinesterase.Transgenic research · 2009Article
- The Nuclear Factor I (NFI) gene family in mammary gland development and function.Journal of mammary gland biology and neoplasia · 2003Review
- A new beta-lactoglobulin-based vector targets luciferase cDNA expression to the mammary gland of transgenic mice.Transgenic research · 2001Article
- Differential interactions of specific nuclear factor I isoforms with the glucocorticoid receptor and STAT5 in the cooperative regulation of WAP gene transcription.Molecular and cellular biology · 2001Article
- Differential binding of NF1 transcription factor to P53 gene promoter and its depletion in human breast tumours.Molecular biology reports · 1999Article
- Introduction of a proximal Stat5 site in the murine alpha-lactalbumin promoter induces prolactin dependency in vitro and improves expression frequency in vivo.Transgenic research · 1999Article
- Mammary gland expression of mouse mammary tumor virus is regulated by a novel element in the long terminal repeat.Journal of virology · 1999Article
- Studies of the regulation of the mouse carboxyl ester lipase gene in mammary gland.The Biochemical journal · 1998Article
- Developmental and hormonal regulation of protein N-glycosylation in the mammary gland.Journal of mammary gland biology and neoplasia · 1998Review
- Beta1,4-galactosyltransferase and lactose biosynthesis: recruitment of a housekeeping gene from the nonmammalian vertebrate gene pool for a mammary gland specific function.Journal of mammary gland biology and neoplasia · 1998Review
- Characterization of BCE-1, a transcriptional enhancer regulated by prolactin and extracellular matrix and modulated by the state of histone acetylation.Molecular and cellular biology · 1998Article
- Developing a mammary gland is a stat affair.Journal of mammary gland biology and neoplasia · 1997Review
- Molecular mechanisms of hormone controlled gene expression in the breast.Molecular biology reports · 1997Review
- Characterization, chromosomal localization, and genetic variation of the porcine heart fatty acid-binding protein gene.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Variants within the 5'-flanking regions of bovine milk-protein-encoding genes. III. Genes encoding the Ca-sensitive caseins αs1, α s2 and β.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The minimal 5' regulatory region of the sheep beta-lactoglobulin gene (BLG), as defined in transgenic mice, was used to identify nuclear factors which may be involved in milk protein gene expression in the lactating mammary gland. This 406bp promoter region was dissected into short, overlapping, double-stranded oligonucleotides to facilitate identification of the bound proteins. A variety of sites, for both known and previously undescribed DNA-binding proteins, are occupied in vitro. Some of these factors were investigated in detail. Two forms of nuclear factor I (NFI), which have different recognition site affinities, are present in nuclear extracts from lactating mammary gland and bind to at least 5 sites in this BLG control element. In addition, a factor (milk protein binding factor, MPBF) which is specific to extracts from both mouse and sheep lactating mammary gland binds to 3 BLG promoter sites and may be a milk protein gene transcription factor.
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