ArticleExperimental gerontology2007
Genes that may modulate longevity in C. elegans in both dauer larvae and long-lived daf-2 adults.
Article in Experimental gerontology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
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- The Mitochondrial PHB Complex Determines Lipid Composition and Interacts With the Endoplasmic Reticulum to Regulate Ageing.Frontiers in physiology · 2021Article
- Untangling Longevity, Dauer, and Healthspan in Caenorhabditis elegans Insulin/IGF-1-Signalling.Gerontology · 2018Article
- Analysis of the effect of the mitochondrial prohibitin complex, a context-dependent modulator of longevity, on the C. elegans metabolome.Biochimica et biophysica acta · 2015Article
- LC-MS proteomics analysis of the insulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism.Journal of proteome research · 2014Article
- Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans.Molecular & cellular proteomics : MCP · 2013Article
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- Divergent gene expression in the conserved dauer stage of the nematodes Pristionchus pacificus and Caenorhabditis elegans.BMC genomics · 2012Article
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- Effect of life history on microRNA expression during C. elegans development.RNA (New York, N.Y.) · 2011Article
- Article
- Deep SAGE analysis of the Caenorhabditis elegans transcriptome.Nucleic acids research · 2010Article
- Molecular time-course and the metabolic basis of entry into dauer in Caenorhabditis elegans.PloS one · 2009Article
- Discovery of novel alternatively spliced C. elegans transcripts by computational analysis of SAGE data.BMC genomics · 2007Article
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5 authors at 1 institution in 1 country.
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Abstract
We used Serial Analysis of Gene Expression (SAGE) to compare the global transcription profiles of long-lived mutant daf-2 adults and dauer larvae, aiming to identify aging-related genes based on similarity of expression patterns. Genes that are expressed similarly in both long-lived types potentially define a common life-extending program. Comparison of eight SAGE libraries yielded a set of 120 genes, the expression of which was significantly different in long-lived worms vs. normal adults. The gene annotations indicate a strong link between oxidative stress and life span, further supporting the hypothesis that metabolic activity is a major determinant in longevity. The SAGE data show changes in mRNA levels for electron transport chain components, elevated expression of glyoxylate shunt enzymes and significantly reduced expression for components of the TCA cycle in longer-lived nematodes. We propose a model for enhanced longevity through a cytochrome c oxidase-mediated reduction in reactive oxygen species commonly held to be a major contributor to aging.
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