ArticleVirology2007
Induction of promyelocytic leukemia (PML) oncogenic domains (PODs) by papillomavirus.
Article in Virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- The Epithelial Immune Response to Human Papillomavirus Infection.Pathogens (Basel, Switzerland) · 2025Review
- Autophagic Degradation of Misfolded Nuclear Receptor Co-repressor (NCoR) Is Linked to the Growth of Tumor Cells in HBX Positive Hepatocellular Carcinoma (HCC).Frontiers in oncology · 2019Article
- Sp100 colocalizes with HPV replication foci and restricts the productive stage of the infectious cycle.PLoS pathogens · 2017Article
- Involvement of Nucleophosmin (NPM1/B23) in Assembly of Infectious HPV16 Capsids.Papillomavirus research (Amsterdam, Netherlands) · 2015Article
- DAXX modulates human papillomavirus early gene expression and genome replication in U2OS cells.Virology journal · 2015Article
- CD66+ cells in cervical precancers are partially differentiated progenitors with neoplastic traits.Cancer research · 2014Article
- DNA virus replication compartments.Journal of virology · 2014Review
- Article
- Expression of mitochondrial non-coding RNAs (ncRNAs) is modulated by high risk human papillomavirus (HPV) oncogenes.The Journal of biological chemistry · 2012Article
- Design stars: how small DNA viruses remodel the host nucleus.Future virology · 2012Article
- Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk viruses.Virology · 2012Review
- Virion assembly factories in the nucleus of polyomavirus-infected cells.PLoS pathogens · 2012Article
- Article
- Targeting promyelocytic leukemia protein: a means to regulating PML nuclear bodies.International journal of biological sciences · 2009Review
- Expression pattern and subcellular localization of human papillomavirus minor capsid protein L2.The American journal of pathology · 2009Article
- HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies.Cancer research · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Promyelocytic leukemia oncogenic domains (PODs), also called nuclear domain 10 (ND10), are subnuclear structures that have been implicated in a variety of cellular processes as well as the life cycle of DNA viruses including papillomaviruses. In order to investigate the interplay between papillomaviruses and PODs, we analyzed the status of PODs in organotypic raft cultures of human keratinocytes harboring HPV genome that support the differentiation-dependent HPV life cycle. The number of PODs per nucleus was increased in the presence of HPV genomes selectively within the poorly differentiated layers but was absent in the terminally differentiated layers of the stratified epithelium. This increase in PODs was correlated with an increase in abundance of post-translationally modified PML protein. Neither the E2-dependent transcription nor viral DNA replication was reliant upon the presence of PML. Implications of these findings in terms of HPV's interaction with its host are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.