ArticleNeuropharmacology2007
Pre- and postsynaptic effects of kainate on layer II/III pyramidal cells in rat neocortex.
Article in Neuropharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Kainate Receptor-Mediated Depression of Glutamate Release Involves Protein Kinase A in the Cerebellum.International journal of molecular sciences · 2019Article
- Development of Cortical Pyramidal Cell and Interneuronal Dendrites: a Role for Kainate Receptor Subunits and NETO1.Molecular neurobiology · 2019Article
- Kainate Receptors Play a Role in Modulating Synaptic Transmission in the Olfactory Bulb.Neuroscience · 2018Article
- Cerebellar Kainate Receptor-Mediated Facilitation of Glutamate Release Requires CaFrontiers in molecular neuroscience · 2018Article
- Non-canonical Mechanisms of Presynaptic Kainate Receptors Controlling Glutamate Release.Frontiers in molecular neuroscience · 2018Review
- Effects of Ketamine on Neuronal Spontaneous Excitatory Postsynaptic Currents and Miniature Excitatory Postsynaptic Currents in the Somatosensory Cortex of Rats.Iranian journal of medical sciences · 2016Article
- Further observations on the behavioral and neural effects of bone marrow stromal cells in rodent pain models.Molecular pain · 2016Article
- Kainic Acid-Induced Excitotoxicity Experimental Model: Protective Merits of Natural Products and Plant Extracts.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Presynaptic facilitation of glutamate release in the basolateral amygdala: a mechanism for the anxiogenic and seizurogenic function of GluK1 receptors.Neuroscience · 2012Article
- Physiology and pathology of calcium signaling in the brain.Frontiers in pharmacology · 2012Article
- Kainic Acid-induced neurotoxicity: targeting glial responses and glia-derived cytokines.Current neuropharmacology · 2011Article
- Responses of developing pedunculopontine neurons to glutamate receptor agonists.Journal of neurophysiology · 2011Article
- Presynaptic NMDA receptors mediate IPSC potentiation at GABAergic synapses in developing rat neocortex.PloS one · 2011Article
- Kainic acid-induced neurodegenerative model: potentials and limitations.Journal of biomedicine & biotechnology · 2011Review
- GluR5-mediated glutamate signaling regulates hypothalamo-pituitary-adrenocortical stress responses at the paraventricular nucleus and median eminence.Psychoneuroendocrinology · 2009Article
- Robust short-latency perisomatic inhibition onto neocortical pyramidal cells detected by laser-scanning photostimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Contrary roles of kainate receptors in transmitter release at corticothalamic synapses onto thalamic relay and reticular neurons.The Journal of physiology · 2009Article
- Calcium-permeable presynaptic kainate receptors involved in excitatory short-term facilitation onto somatostatin interneurons during natural stimulus patterns.Journal of neurophysiology · 2009Article
- Calcium release via activation of presynaptic IP3 receptors contributes to kainate-induced IPSC facilitation in rat neocortex.Neuropharmacology · 2008Article
- The role of GLU K5-containing kainate receptors in entorhinal cortex gamma frequency oscillations.Neural plasticity · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Kainate receptors mediate both direct excitatory and indirect modulatory actions in the CNS. We report here that kainate has both pre- and postsynaptic actions in layer II/III pyramidal neurons of rat prefrontal cortex. Application of low concentration of kainate (50-500 nM) increased the amplitude of evoked excitatory postsynaptic currents (EPSCs) whereas higher concentrations (3 microM) caused a decrease. The frequency of spontaneous and miniature (action potential-independent) EPSCs was increased by low concentrations of kainate without affecting their amplitudes, suggesting a presynaptic mechanism of action. The facilitatory and inhibitory effects of kainate were mimicked by the GluR5 subunit selective agonist ATPA. In addition to decreasing EPSC amplitudes, high concentrations of kainate and ATPA induced an inward current which was not blocked by AMPA- or NMDA-receptor antagonists GYKI52466 and D-APV, respectively. The inward currents were blocked by the AMPA/KA receptor antagonist CNQX, indicating the presence of postsynaptic kainate receptors. Single shock stimulation in the presence of GYKI52466 and D-APV evoked an EPSC which was blocked by CNQX. The GluR5 antagonist LY382884 changed paired-pulse facilitation to paired pulse depression, indicating that synaptically released glutamate can activate presynaptic kainate receptors. These results suggest that kainate receptors containing GluR5 subunits play a major role in glutamatergic transmission in rat neocortex, having both presynaptic modulatory and direct postsynaptic excitatory actions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.