ArticleBiochemical and biophysical research communications2007
LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway.
Article in Biochemical and biophysical research communications, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Proteomic Profile Regulated by the Immunomodulatory Jusvinza Drug in Neutrophils Isolated from Rheumatoid Arthritis Patients.Biomedicines · 2024Article
- BYHWD Alleviates Inflammatory Response by NIK-Mediated Repression of the Noncanonical NF-κB Pathway During ICH Recovery.Frontiers in pharmacology · 2021Article
- Functional interplay between NF-κB-inducing kinase and c-Abl kinases limits response to Aurora inhibitors in multiple myeloma.Haematologica · 2019Article
- Increased LIGHT expression and activation of non-canonical NF-κB are observed in gastric lesions of MyD88-deficient mice upon Helicobacter felis infection.Scientific reports · 2019Article
- ZFP91: A Noncanonical NF-BioMed research international · 2016Article
- The Complex Role of STAT3 in Viral Infections.Journal of immunology research · 2015Review
- Significant involvement of nuclear factor-κB-inducing kinase in proper differentiation of αβ and γδ T cells.Immunology · 2014Article
- The TRAF3 adaptor protein drives proliferation of anaplastic large cell lymphoma cells by regulating multiple signaling pathways.Cell cycle (Georgetown, Tex.) · 2014Article
- Mechanisms of persistent activation of the androgen receptor in CRPC: recent advances and future perspectives.World journal of urology · 2012Review
- IκB kinases modulate the activity of the androgen receptor in prostate carcinoma cell lines.Neoplasia (New York, N.Y.) · 2012Article
- NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses.The Journal of experimental medicine · 2011Article
- Construction of NF-κB-targeting RNAi adenovirus vector and the effect of NF-κB pathway on proliferation and apoptosis of vascular endothelial cells.Molecular biology reports · 2011Article
- NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis.PloS one · 2010Article
- NF-κB inducing kinase: a key regulator in the immune system and in cancer.Cytokine & growth factor reviews · 2010Review
- Epstein-Barr virus latent membrane protein 1 modulates distinctive NF- kappaB pathways through C-terminus-activating region 1 to regulate epidermal growth factor receptor expression.Journal of virology · 2010Article
- Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?.Annals of the New York Academy of Sciences · 2009Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Stat3, a member of the signal transducers and activators of transcription (STAT) family, is a key signal transduction protein activated by numerous cytokines, growth factors, and oncoproteins that controls cell proliferation, differentiation, development, survival, and inflammation. Constitutive activation of Stat3 has been found frequently in a wide variety of human tumors and induces cellular transformation and tumor formation. In this study, we demonstrated that LIGHT, a member of tumor necrosis factor superfamily, activates Stat3 in cancer cells. LIGHT induces dose-dependent activation of Stat3 by phosphorylation at both the tyrosine 705 and serine 727 residues. The activation of Stat3 by LIGHT appears to be mediated by NIK phosphorylation. Expression of a kinase-inactive NIK mutant abolished LIGHT induced Stat3 activation. Overexpression of an active NIK induces Stat3 activation by phosphorylation at the both tyrosine 705 and serine 727 residues. Activation of Stat3 by NIK requires NIK kinase activity as showed by kinase assays. In addition, LIGHT increases the expression of Stat3 target genes including cyclin D1, survivin, and Bcl-xL, and stimulates human LNCaP prostate cancer cell growth in vitro which can be blocked by expression of a dominant-negative Stat3 mutant. Taken together, these results indicate that in addition to activating NF-kappaB/p52, LIGHT also activates Stat3. Activation of Stat3 together with activating non-canonical NF-kappaB/p52 signaling by LIGHT may maximize its effects on cellular proliferation, survival, and inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.