ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2007
Vascular calcification in middle age and long-term risk of hip fracture: the Framingham Study.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Prognostic Value of Abdominal Aortic Calcification: A Systematic Review and Meta-Analysis of Observational Studies.Journal of the American Heart Association · 2021Pooled it
- Abdominal aortic calcification and the risk of bone fractures: a meta-analysis of prospective cohort studies.Journal of bone and mineral metabolism · 2018Pooled it
- Meta-analysis of hypertension and osteoporotic fracture risk in women and men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Pooled it
- (Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis.Arthritis research & therapy · 2011Pooled it
- Long-Term Atherosclerotic Vascular Disease Risk and Prognosis in Elderly Women With Abdominal Aortic Calcification on Lateral Spine Images Captured During Bone Density Testing: A Prospective Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Trial
- Abdominal aortic calcification as an opportunistic marker of reduced CT-derived vertebral bone density in osteoporotic vertebral fractures.Brain & spine · 2026Article
- Association of Trabecular Bone Score-Adjusted Fracture Risk Assessment Tool with Coronary Artery Calcification in Women.Diagnostics (Basel, Switzerland) · 2022Article
- FRAX® Fracture Risks Are Associated with Coronary Artery Calcification Score.Disease markers · 2017Article
- Osteoporosis in men: findings from the Osteoporotic Fractures in Men Study (MrOS).Therapeutic advances in musculoskeletal disease · 2016Review
- Arterial stiffness is not associated with bone parameters in an elderly hyperhomocysteinemic population.Journal of bone and mineral metabolism · 2016Article
- Article
- Vertebral fractures on routine chest computed tomography: relation with arterial calcifications and future cardiovascular events.The international journal of cardiovascular imaging · 2015Article
- Detection of carotid artery calcification on the panoramic images of post-menopausal females is significantly associated with severe abdominal aortic calcification: a risk indicator of future adverse vascular events.Dento maxillo facial radiology · 2015Article
- Role of bone mineral density in the inverse relationship between body size and aortic calcification: results from the Baltimore Longitudinal Study of Aging.Atherosclerosis · 2014Article
- High hip fracture risk in men with severe aortic calcification: MrOS study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Association of volumetric bone mineral density with abdominal aortic calcification in African ancestry men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Gender difference in bone loss and vascular calcification associated with age.Korean circulation journal · 2013Article
- Severity of aortic calcification is positively associated with vertebral fracture in older men--a densitometry study in the STRAMBO cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Article
- Cardiovascular and noncardiovascular disease associations with hip fractures.The American journal of medicine · 2013Article
- Cardiovascular diseases in older patients with osteoporotic hip fracture: prevalence, disturbances in mineral and bone metabolism, and bidirectional links.Clinical interventions in aging · 2013Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
unlabelledOsteoporosis and atherosclerosis frequently occur in the same individuals and may share similar pathogenic mechanisms. This study examined the relation between severity of aortic calcification in middle-age years and subsequent risk of hip fracture in women and men in the population-based Framingham Study.
introductionWe assessed vascular calcification in women and men in middle age and risk of hip fracture at advanced age. MATERIALS AND
methodsParticipants included 2499 Framingham cohort members (mean age, 61 yr; range, 47-80 yr). Semiquantitative methods were used to determine severity of abdominal aortic calcification on baseline radiographs. Information on potential confounding factors was obtained from study examinations conducted at, or before, baseline radiography. Hip fractures were ascertained by active surveillance and confirmed by medical records.
resultsThirty-five-year cumulative incidence of hip fracture was 16% in women and 5% in men with prevalent aortic calcification at baseline (score 1+) and 14% in women and 4% in men without aortic calcification (score 0). Hazard ratios (HRs) and 95% CIs for hip fracture did not increase from the lowest to the highest category of aortic calcification. HRs were 1.0, 1.2 (95% CI, 0.9-1.8), 1.2 (95% CI, 0.7-1.9), 1.1 (95% CI, 0.7-1.7), and 1.4 (95% CI, 0.8-2.3) in women (p for trend = 0.44) and 1.0, 1.8 (95% CI, 0.8-3.8), 1.8 (95% CI, 0.7-4.6), 1.5 (95% CI, 0.6-3.9), and 1.2 (95% CI, 0.2-5.7) in men (p for trend = 0.29) for aortic calcification scores 0 (reference), 1-4, 4-5, 6-10, and 11+, respectively. However, aortic calcification score was strongly associated with increased risk of death (p for trend < 0.0001 in women and men). HRs (95% CIs) for mortality from the lowest to highest aortic calcification score were 1.0, 1.6 (1.4-1.9), 1.7 (1.4-2.1), 1.8 (1.5-2.2), and 2.1 (1.7-2.6) for women, and for men were 1.0, 1.4 (1.1-1.6), 1.4 (1.2-1.8), 1.6 (1.3-2.0), and 1.9 (1.5-2.5).
conclusionsVascular calcification in middle-aged adults does not increase long-term hip fracture risk.
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