ArticlePLoS genetics2007
Reverse genetic analysis of the yeast RSC chromatin remodeler reveals a role for RSC3 and SNF5 homolog 1 in ploidy maintenance.
Article in PLoS genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Integration of transcription coregulator complexes with sequence-specific DNA-binding factor interactomes.Biochimica et biophysica acta. Gene regulatory mechanisms · 2021Article
- Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes.eLife · 2020Article
- Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement.eLife · 2019Article
- The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion.The Journal of cell biology · 2018Article
- Article
- Hsp90 and p23 Molecular Chaperones Control Chromatin Architecture by Maintaining the Functional Pool of the RSC Chromatin Remodeler.Molecular cell · 2016Article
- Genetic instability in budding and fission yeast-sources and mechanisms.FEMS microbiology reviews · 2015Review
- Review
- Article
- The RSC complex localizes to coding sequences to regulate Pol II and histone occupancy.Molecular cell · 2014Article
- Chromatin remodelling complex RSC promotes base excision repair in chromatin of Saccharomyces cerevisiae.DNA repair · 2014Article
- The RSC chromatin remodeling complex has a crucial role in the complete remodeler set for yeast PHO5 promoter opening.Nucleic acids research · 2014Article
- Bridge-induced chromosome translocation in yeast relies upon a Rad54/Rdh54-dependent, Pol32-independent pathway.PloS one · 2013Article
- Chromatin and the genome integrity network.Nature reviews. Genetics · 2013Review
- The two different isoforms of the RSC chromatin remodeling complex play distinct roles in DNA damage responses.PloS one · 2012Article
- Article
- The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4.The EMBO journal · 2011Article
- ATP-dependent chromatin remodeling: genetics, genomics and mechanisms.Cell research · 2011Review
- Article
- Features of cryptic promoters and their varied reliance on bromodomain-containing factors.PloS one · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The yeast "remodels the structure of chromatin" (RSC) complex is a multi-subunit "switching deficient/sucrose non-fermenting" type ATP-dependent nucleosome remodeler, with human counterparts that are well-established tumor suppressors. Using temperature-inducible degron fusions of all the essential RSC subunits, we set out to map RSC requirement as a function of the mitotic cell cycle. We found that RSC executes essential functions during G1, G2, and mitosis. Remarkably, we observed a doubling of chromosome complements when degron alleles of the RSC subunit SFH1, the yeast hSNF5 tumor suppressor ortholog, and RSC3 were combined. The requirement for simultaneous deregulation of SFH1 and RSC3 to induce these ploidy shifts was eliminated by knockout of the S-phase cyclin CLB5 and by transient depletion of replication origin licensing factor Cdc6p. Further, combination of the degron alleles of SFH1 and RSC3, with deletion alleles of each of the nine Cdc28/Cdk1-associated cyclins, revealed a strong and specific genetic interaction between the S-phase cyclin genes CLB5 and RSC3, indicating a role for Rsc3p in proper S-phase regulation. Taken together, our results implicate RSC in regulation of the G1/S-phase transition and establish a hitherto unanticipated role for RSC-mediated chromatin remodeling in ploidy maintenance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.