ArticlePLoS genetics2007
Localizing recent adaptive evolution in the human genome.
Article in PLoS genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 246 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
246 citing papers in PubMed, 525 citations in OpenAlex.
- Genomic insights into natural selection in recent human history.Nature reviews. Genetics · 2026Review
- Article
- Coordinated Temporal Dynamics of Glucocorticoid Receptor Binding and Chromatin Landscape Drive Transcriptional Regulation.bioRxiv : the preprint server for biology · 2026Article
- Not by Selection Alone: Expanding the Scope of Gene-Culture Coevolution.Evolutionary anthropology · 2025Review
- Review
- A whole-genome scan for evidence of positive and balancing selection in aye-ayes (Daubentonia madagascariensis) utilizing a well-fit evolutionary baseline model.G3 (Bethesda, Md.) · 2025Article
- Sweeps in Space: Leveraging Geographic Data to Identify Beneficial Alleles in Anopheles gambiae.Molecular biology and evolution · 2025Article
- Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank.Journal of human genetics · 2025Article
- Evolution of long scalp hair in humans.The British journal of dermatology · 2025Review
- Advances in Whole Genome Sequencing: Methods, Tools, and Applications in Population Genomics.International journal of molecular sciences · 2025Review
- Digital Image Processing to Detect Adaptive Evolution.Molecular biology and evolution · 2024Article
- A whole-genome scan for evidence of recent positive and balancing selection in aye-ayes (bioRxiv : the preprint server for biology · 2024Article
- Genomic patterns of selection in morphometric traits across diverse Indian cattle breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Analysis of 206 whole-genome resequencing reveals selection signatures associated with breed-specific traits in Hu sheep.Evolutionary applications · 2024Article
- Deciphering climate resilience in Indian cattle breeds by selection signature analyses.Tropical animal health and production · 2024Article
- Genomic signatures of selection, local adaptation and production type characterisation of East Adriatic sheep breeds.Journal of animal science and biotechnology · 2023Article
- Human genetic adaptation related to cellular zinc homeostasis.PLoS genetics · 2023Article
- Evolutionary Psychology and Normal Science: in Search of a Unifying Research Program.Integrative psychological & behavioral science · 2023Article
- Developmental mechanisms underlying the evolution of human cortical circuits.Nature reviews. Neuroscience · 2023Review
- The alternative transcription and expression characterization ofFrontiers in genetics · 2023Article
186 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Identifying genomic locations that have experienced selective sweeps is an important first step toward understanding the molecular basis of adaptive evolution. Using statistical methods that account for the confounding effects of population demography, recombination rate variation, and single-nucleotide polymorphism ascertainment, while also providing fine-scale estimates of the position of the selected site, we analyzed a genomic dataset of 1.2 million human single-nucleotide polymorphisms genotyped in African-American, European-American, and Chinese samples. We identify 101 regions of the human genome with very strong evidence (p < 10(-5)) of a recent selective sweep and where our estimate of the position of the selective sweep falls within 100 kb of a known gene. Within these regions, genes of biological interest include genes in pigmentation pathways, components of the dystrophin protein complex, clusters of olfactory receptors, genes involved in nervous system development and function, immune system genes, and heat shock genes. We also observe consistent evidence of selective sweeps in centromeric regions. In general, we find that recent adaptation is strikingly pervasive in the human genome, with as much as 10% of the genome affected by linkage to a selective sweep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.