ArticleMolecular and cellular biochemistry2007
Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2.
Article in Molecular and cellular biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 19 citations in OpenAlex.
- REV7: a small but mighty regulator of genome maintenance and cancer development.Frontiers in oncology · 2024Review
- Review
- REV7: Jack of many trades.Trends in cell biology · 2021Review
- High expression of REV7 is an independent prognostic indicator in patients with diffuse large B-cell lymphoma treated with rituximab.International journal of hematology · 2015Article
- REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ.Nucleic acids research · 2015Article
- Rev7/Mad2B plays a critical role in the assembly of a functional mitotic spindle.Cell cycle (Georgetown, Tex.) · 2015Article
- Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells.Cancer science · 2014Article
- The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse.The Journal of biological chemistry · 2013Article
- Loss of fragile histidine triad and amplification of 1p36.22 and 11p15.5 in primary gastric adenocarcinomas.World journal of gastroenterology · 2012Article
- Article
- The oncogenic role of Yin Yang 1.Critical reviews in oncogenesis · 2011Review
- RIOK3 interacts with caspase-10 and negatively regulates the NF-kappaB signaling pathway.Molecular and cellular biochemistry · 2009Article
- The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle.PloS one · 2009Article
- MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation.The Journal of biological chemistry · 2009Article
- Molecular signature of cell cycle exit induced in human T lymphoblasts by IL-2 withdrawal.BMC genomics · 2009Article
- Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance.Microbiology and molecular biology reviews : MMBR · 2009Review
- SBF transcription factor complex positively regulates UV mutagenesis in Saccharomyces cerevisiae.Biochemical and biophysical research communications · 2009Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HCCA2 (hepatocellular carcinoma-associated gene 2) was initially identified as a HCC (hepatocellular carcinoma)-specific protein and subsequently, a long splice variant of HCCA2 was identified as a co-activator of transcription factor YY1 (Yin Yang 1). To investigate the role of HCCA2 in HCC genesis and progression, we screened a human fetal liver cDNA library and identified a novel HCCA2-interacting protein, MAD2L2 (MAD2 mitotic arrest deficient-like 2 (yeast)). The interaction between HCCA2 and MAD2L2 was confirmed by in vitro and in vivo binding assays and the interaction domain was mapped to the N-terminus of HCCA2 by sequential deletion. HCCA2 and MAD2L2 also colocalized in the nucleus of Hela cells. Furthermore, overexpression of HCCA2 led to cell cycle arrest at G0/G1 phase and therefore inhibited cell proliferation. Our research suggests that HCCA2 may play a novel role in cell cycle regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.